Hemostatic action of EGF-endospray on mucosectomy-induced ulcer bleeding animal models
| Autor: | Jin Hee Maeng, Byoung Wook Bang, Su-Geun Yang, Min-Kyoung Kim, Don Haeng Lee |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Endoscope Swine Biomedical Engineering Hemorrhage Endoscopic mucosal resection Gastroenterology Hemostatics Biomaterials Lesion Bleeding time Internal medicine medicine Animals Stomach Ulcer Cell Proliferation Hemostasis Hemostatic Agent Mucous Membrane Epidermal Growth Factor medicine.diagnostic_test business.industry Hydrogels General Medicine Surgery Endoscopy Disease Models Animal Epinephrine Gastric Mucosa Models Animal Swine Miniature Female Rabbits Powders medicine.symptom business Gastric Hemorrhage hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Bio-Medical Materials and Engineering. 25:101-109 |
| ISSN: | 0959-2989 |
| DOI: | 10.3233/bme-141236 |
| Popis: | Gastric bleeding is one of the irritant problems in ulcer patients. In this study, we evaluated hemostatic action of ulcer-coating powder (EGF-endospray) on gastric ulcer animal models. EGF-endospray, containing epidermal growth factor, is designed to be applied through an endoscope. Hemostatic action of the EGF-endospray was evaluated on gastric hemorrhage models of rabbits and micro-pigs. The EGF-endospray was directly applied onto a mucosal resection (MR)-induced gastric bleeding focus in a rabbit model. In a porcine model, the EGF-endospray was applied once via an endoscopy to a bleeding lesion created by endoscopic submucosal dissection. The bleeding focus was then observed via an endoscope. In the rabbit model, EGF-endospray treatment significantly shortened mean bleeding time in comparison with other treatments (104.3 vs 548.0 vs 393.2 s for the EGF-endospray, the non-treated control and the epinephrine injection, respectively). In the micro-pig model, EGF-endospray showed immediate hemostatic action and prolonged covering of the bleeding focus for over 72 h. Histology proved mucosal thickness was more efficiently recovered in all EGF-endospray treated animals. The results of the present study suggest that the EGF-endospray is a promising hemostatic agent for GI bleeding. |
| Databáze: | OpenAIRE |
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