Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland
| Autor: | Michael Osthoff, Agnieszka Wojtowicz, Frederic Tissot, Clara Jørgensen, Steffen Thiel, Stephan Zimmerli, Oscar Marchetti, Nina Khanna, Pierre-Yves Bochud, Marten Trendelenburg, Thomas Bregenzer, Anna Conen, Hans Fankhauser, Ursula Flückiger, Reno Frei, Ulrich Heininger, Roland Hertel, Mario Franciolli, Ospedale San Giovanni, Marisa Dolina, Madeleine Rothen, Olivier Dubuis, Philipp Tarr, Suzanne Graf, Felix Fleisch, Martin Risch, Eva Ritzler, Christian Chuard, Véronique Erard, Dominique Fracheboud, Stéphane Emonet, Daniel Genne, Reto Lienhardt, Jean-Philippe Chave, Corinne Andreutti-Zaugg, Alberto Gallusser, Peter Graber, Rita Monotti, Enos Bernasconi, Martin Krause, Karin Herzog, Rein-Jan Piso, Urs Schibli, Frank Bally, Nicolas Troillet, Lysiane Tissière, Katja Boggian, Thomas Bruderer, Jacques Gubler, Gerhard Eich, Christoph Berger |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Critical Care Observational Study Biology law.invention Young Adult 03 medical and health sciences 0302 clinical medicine law Lectins Genotype Journal Article medicine Humans Candidiasis Invasive Genetic Predisposition to Disease Prospective Studies 610 Medicine & health Prospective cohort study Aged Candida Mannan-binding lectin Aged 80 and over Research Support Non-U.S. Gov't Middle Aged MBL deficiency medicine.disease Intensive care unit Intensive Care Units 030104 developmental biology Infectious Diseases Lectin pathway Immunology Cohort Intraabdominal Infections Female Switzerland 030215 immunology Cohort study |
| Zdroj: | Osthoff, M, Wojtowicz, A, Tissot, F, Jørgensen, C, Thiel, S, Zimmerli, S, Marchetti, O, Khanna, N, Bochud, P-Y, Trendelenburg, M & Fungal Infection Network of Switzerland (FUNGINOS) 2016, ' Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland ', Journal of Infection, vol. 72, no. 3, pp. 377-85 . https://doi.org/10.1016/j.jinf.2015.12.011 |
| ISSN: | 0163-4453 |
| Popis: | OBJECTIVES: Human studies on the role of mannose-binding lectin (MBL) in patients with invasive candidiasis have yielded conflicting results. We investigated the influence of MBL and other lectin pathway proteins on Candida colonization and intra-abdominal candidiasis (IAC) in a cohort of high-risk patients.METHODS: Prospective observational cohort study of 89 high-risk intensive-care unit (ICU) patients. Levels of lectin pathway proteins at study entry and six MBL2 single-nucleotide polymorphisms were analyzed by sandwich-type immunoassays and genotyping, respectively, and correlated with development of heavy Candida colonization (corrected colonization index (CCI) ≥0.4) and occurrence of IAC during a 4-week period.RESULTS: Within 4 weeks after inclusion a CCI ≥0.4 and IAC was observed in 47% and 38% of patients respectively. Neither serum levels of MBL, ficolin-1, -2, -3, MASP-2 or collectin liver 1 nor MBL2 genotypes were associated with a CCI ≥0.4. Similarly, none of the analyzed proteins was found to be associated with IAC with the exception of lower MBL levels (HR 0.74, p = 0.02) at study entry. However, there was no association of MBL deficiency (CONCLUSION: Lectin pathway protein levels and MBL2 genotype investigated in this study were not associated with heavy Candida colonization or IAC in a cohort of high-risk ICU patients. |
| Databáze: | OpenAIRE |
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