Infection and transmission of SARS-CoV-2 in London care homes reporting no cases or outbreaks of COVID-19: prospective observational cohort study, England 2020
| Autor: | Angie Lackenby, Heather Whitaker, Shamez N Ladhani, Zahin Amin-Chowdhury, Edward Wynne-Evans, Nandini Shetty, Emma Crawley-Boevey, Maria Saavedra-Campos, Felicity Aiano, Elena Fernandez Ruiz De Olano, Thomas A.J. Rowland, Jonathan Fok, Suzanne Tang, Richard M. Myers, Kevin E. Brown, Maria Zambon, Kate Dun-Campbell, Bharat Patel, Joanna Ellis, Marina Sanchez Perez, J. Yimmy Chow, Mary Ramsay, Katja Hoschler, Roshni Janarthanan, Karthik Paranthaman, Anita Bell, Amoolya Vusirikala, Thomas Ma, Anna Jeffery-Smith |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
business.industry
Transmission (medicine) Health Policy Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Outbreak Asymptomatic Article Serology SARS-CoV-2 outbreak asymptomatic transmission Oncology care home Pandemic Internal Medicine Seroprevalence Medicine Public aspects of medicine RA1-1270 medicine.symptom business Demography Cohort study |
| Zdroj: | The Lancet Regional Health-Europe The Lancet Regional Health. Europe, Vol 3, Iss, Pp 100038-(2021) |
| ISSN: | 2666-7762 |
| Popis: | Background: Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic. Methods: Five care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks. Findings: Across seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case.Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (rs 0.84, [95% CI 0.51-0.95] p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|