Effect of l-carnitine on cardiotoxicity and apoptosis induced by imatinib through PDGF/ PPARγ /MAPK pathways
| Autor: | Shereen M. El kiki, Mervat M. Omran, Amel B. Ibrahim, Heba H. Mansour |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine MAPK/ERK pathway MAP Kinase Signaling System medicine.drug_class Biophysics Apoptosis Pharmacology Biochemistry Tyrosine-kinase inhibitor Nitric oxide Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Carnitine medicine Animals Rats Wistar Extracellular Signal-Regulated MAP Kinases Molecular Biology Platelet-Derived Growth Factor Cardiotoxicity 030102 biochemistry & molecular biology biology Chemistry Myocardium Glutathione Rats PPAR gamma 030104 developmental biology Imatinib Mesylate biology.protein Platelet-derived growth factor receptor medicine.drug |
| Zdroj: | Archives of Biochemistry and Biophysics. 704:108866 |
| ISSN: | 0003-9861 |
| Popis: | A tyrosine kinase inhibitor Imatinib (IM) is used in the treatment of different varieties of cancers. The current study was designed to explore the beneficial role of l -carnitine against IM-induced cardiotoxicity in rats. Male albino rats received IM (40 mg/kg, i.p.) either alone or/in combination with l -carnitine (100 mg/kg, i.p.) for 7 days. IM increased serum inflammatory cytokines, concomitant with activation of cardiac MAPK, α-SMA, malondialdehyde (MDA) and nitric oxide(NO), decreased cardiac peroxisome proliferator-activated receptor-γ (PPAR-γ) level, superoxide dismutase (SOD) activity, and glutathione (GSH) content. The expression levels of Bcl-2 and PDGF were significantly decreased, while the expression levels of CTGF and BAX were significantly increased in the IM group. The l -carnitine treatment successfully protected the heart as indicated by the improvement of the biochemical and histopathological parameters. l -carnitine didn't affect the serum concentration of IM and increased intracellular concentration in the combination-treated group as measured by the mass spectrometer. Conclusion: l -carnitine abrogated IM-induced cardiac damage and apoptosis via PDGF/PPARγ/MAPK pathways. |
| Databáze: | OpenAIRE |
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