Protective or Risk Factors for Postoperative Pancreatic Fistulas in Malignant Pathology

Autor:	Ana Maria Trofin, Vasilescu A, Eugen Tarcoveanu, Delia Florina Andriesi Rusu, Costel Bradea, N Vlad, Corina Lupascu-Ursulescu, Irene Alexandra Spiridon, Cristian Lupascu
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty business.industry Incidence (epidemiology) Science pancreatic ductal adenocarcinomas Paleontology Postoperative complication histological aspects medicine.disease pancreatic fistula General Biochemistry Genetics and Molecular Biology Article Periampullary Adenocarcinoma Space and Planetary Science Fibrosis Pancreatic fistula Medicine Acute pancreatitis Statistical analysis Risk factor business Ecology Evolution Behavior and Systematics
Zdroj:	Life Life, Vol 11, Iss 1216, p 1216 (2021) Life; Volume 11; Issue 11; Pages: 1216
ISSN:	2075-1729
Popis:	Introduction: Malignant tumors are associated with a low incidence of postoperative pancreatic fistulas. The presence of peritumoral fibrosis is considered the protective factor for the development of postoperative pancreatic fistulas after pancreatic resections for pancreatic ductal adenocarcinomas. Methods: We analyzed a series of 109 consecutive patients with pancreatic resections for malignant pathology: pancreatic ductal adenocarcinomas and periampullary adenocarcinomas. The incidence of postoperative pancreatic fistulas has been reported in tumor histological type, in the presence of peritumoral fibrosis, and in the association between adenocarcinomas and areas of acute pancreatitis. The data obtained were processed with the statistical analysis program SPSS, and statistically significant p were considered at a value p = 0.002. The presence of peritumoral fibrous tissue was observed in 49.31% of cases without pancreatic fistulas, and in 54.54% of cases that developed this postoperative complication (p = 0.5). Also, the peritumoral fibrous tissue had a uniform distribution depending on the main diagnosis (56.14% in pancreatic ductal adenocarcinoma group vs. 37.04% in periampullary adenocarcinoma group, with a p = 0.08). In the group of patients who associated areas of acute pancreatitis on the resections, the incidence of postoperative pancreatic fistulas was 7.8 times higher (30% vs. 3.8%, p = 0.026). Conclusions: Peritumoral fibrous tissue was not a factor involved in the developing of postoperative pancreatic fistulas. The association of adenocarciomas with areas of acute pancreatitis has led to a significant increase in postoperative pancreatic fistulas, which is a significant and independent risk factor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6661a701f5c22c279771119d2b1d0f https://pubmed.ncbi.nlm.nih.gov/34833092 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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