Assessment of pre-operative maropitant citrate use in macaque (Macaca fasicularis & Macaca mulatta)neurosurgical procedures
| Autor: | Jaclyn R. Steinbach, Elizabeth A. Dierks, Shu Chang, Jamus MacGuire, Gordon S. Roble |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Quinuclidines medicine.drug_class Macaque 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics 030202 anesthesiology biology.animal Blood plasma Animals Medicine Antiemetic Potency Prospective Studies Retrospective Studies General Veterinary biology business.industry Monkey Diseases Macaca mulatta Macaca fascicularis chemistry Pharmacodynamics Anesthesia Postoperative Nausea and Vomiting Preoperative Period Vomiting Antiemetics Animal Science and Zoology medicine.symptom business Maropitant 030217 neurology & neurosurgery |
| Zdroj: | Journal of Medical Primatology. 47:178-184 |
| ISSN: | 0047-2565 |
| Popis: | Background Retrospective analysis of post-operative vomiting (POV) in non-human primates at our institution was 11%. Based on this additional risk factor for post-operative complications, we aimed to eliminate or decrease POV by adding an antiemetic, maropitant citrate, to the pre-medication protocol. Methods Retrospective and prospective data were collected over a 5-year period from 46 macaques of two species during 155 procedures. Additionally, blood was collected from five Macaca mulatta to perform a pharmacokinetic analysis. Results A 1 mg/kg subcutaneous dose of maropitant given pre-operatively significantly decreased POV. Findings indicated post-neurosurgical emesis in Macaca fasicularis was significantly greater than in Macaca mulatta. Pharmacokinetic analysis of maropitant in Macaca mulatta determined the mean maximum plasma concentration to be 113 ng/mL. Conclusions Maropitant administration prior to anesthesia for neurosurgeries decreased our incidence of POV to 1%. The plasma concentration reaches the proposed plasma level for clinical efficacy approximately 20 minutes after administration. |
| Databáze: | OpenAIRE |
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