Helicobacter pylori can be related to carotid intima-media thickness, epicardial adipose tissue thickness and serum neutrophil gelatinase-associated lipocalin (NGAL) levels
| Autor: | Osman Zikrullah Sahin, Bayram Kizilkaya, Recep Bedir, Z Karadag, Halil Rakici, Erkan Cure, Muhammed Ali Ayvaz, Medine Cumhur Cure, T Sehitoglu |
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| Přispěvatelé: | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Bedir, Recep, Kızılkaya, Bayram |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Economics and Econometrics medicine.medical_specialty Inflammation Lipocalin Carotid Intima-Media Thickness Gastroenterology Helicobacter Infections 03 medical and health sciences Lipocalin-2 Internal medicine Materials Chemistry Media Technology medicine Humans Carotid intima-media thickness 030102 biochemistry & molecular biology biology Helicobacter pylori business.industry Forestry Atherosclerosis biology.organism_classification Upper gastrointestinal endoscopy Neutrophil gelatinase-associated lipocalin Epicardial adipose tissue thickness Adipose Tissue Intima-media thickness Subclinical atherosclerosis Epicardial adipose tissue medicine.symptom Neutrophilic gelatinase-associated lipocalin business |
| Popis: | cure, erkan/0000-0001-7807-135X; Cure, Medine Cumhur/0000-0001-9253-6459 WOS: 000432448800010 PubMed: 29749246 BACKGROUND: Helicobacter pylori (HP) affects the cardiovascular system. Our aim in this study was to evaluate, whether an infection with HP causes subclinical atherosclerosis. METHODS: We included 90 patients with dyspeptic symptoms in this study. the patients underwent an upper gastrointestinal endoscopy and biopsies were taken. the patients were grouped according to histopathologic examination, as HP infection negative (n = 21), HP infection positive (+) (n = 23), HP infection (++) (n = 22), HP infection (+++), (n = 24). RESULTS: the neutrophilic gelatinase-associated lipocalin (NGAL) and high-sensitive C-reactive protein (hs-CRP) levels and the carotid intima-media thickness (cIMT) and epicardial adipose tissue (EAT) thickness in the HP negative group were significantly lower than the NGAL (p < 0.001) and hs-CRP (p < 0.001) levels and the cIMT (p < 0.008) and EAT (p < 0.008) thickness in the HP (+++) group. There was a strong correlation between the serum NGAL and hs-CRP levels, cIMT and EAT thickness. CONCLUSION: HP-infection can lead to subclinical atherosclerosis via chronic inflammation. the higher the activity of HP infection, the higher the acceleration of atherosclerosis (Tab. 3, Fig. 2, Ref. 46). Text in PDF www.elis.sk. |
| Databáze: | OpenAIRE |
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