Myofibroblastes et membranes fibrovasculaires rétiniennes
| Autor: | Guy Donati, Giulio Gabbiani, M.-L. Bochatay-Piallat, Mireille Redard, Constantin J. Pournaras, A. D. Kapetanios |
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| Rok vydání: | 1998 |
| Předmět: |
Proliferative vitreoretinopathy
Pathology medicine.medical_specialty Contraction (grammar) macromolecular substances ddc:616.07 Biology Diabetic Retinopathy/ pathology Retinal Detachment/pathology medicine Humans Cell Movement/physiology Retinal detachment Cell migration medicine.disease Epiretinal Membrane/ pathology Fibroblasts/pathology Ophthalmology Desmin/metabolism Membrane Actins/metabolism Myosins/metabolism Vitreoretinopathy Proliferative/ pathology Cell Division/ physiology Epiretinal membrane Myofibroblast Transforming Growth Factor beta/metabolism Immunostaining |
| Zdroj: | Klinische Monatsblätter für Augenheilkunde, Vol. 212, No 5 (1998) pp. 356-358 |
| ISSN: | 1439-3999 0023-2165 |
| DOI: | 10.1055/s-2008-1034905 |
| Popis: | INTRODUCTION: Epiretinal tissue proliferations occurring during the evolution of ischemic microangiopathies or preretinal diseases are tough to cause retinal detachment by traction mechanisms. Cellular migration/proliferations and finally contraction are tough to be the pathogenic element. Myofibroblasts are contractile cells having features intermediate between those of the fibroblasts and smooth muscle. We conducted a study to explore whether such cells are present in preretinal membranes. MATERIALS AND METHODS: 8 membranes, preelevated during vitrectomy for proliferative vitreoretinopathy or diabetic proliferative vitreoretinopathy, were analysed with immunostaining technique searching for alpha-actine smooth muscle, desmine, which are specific markers for myofibroblasts and TGF-beta1, that is considered as the mean factor promoting the transformation of fibroblasts into myofibroblasts. RESULTS: All the histological preparation showed abundant staining with antibody against alpha-actine smooth muscle, desmine and TGF-beta1. CONCLUSIONS: Myofibroblasts are one of the major cellular element of preretinal membranes. They are scattered throughout the membrane and seem to account for their contractile properties. |
| Databáze: | OpenAIRE |
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