Drug metabolism in diabetic subjects with fatty livers
| Autor: | U. Pitkänen, Pasi I. Salmela, HI Pirttiaho, Eero A. Sotaniemi, R. O. Pelkonen, PV Luoma |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Drug medicine.medical_specialty Cytochrome media_common.quotation_subject Cytochrome P-450 Enzyme System Internal medicine medicine Humans Pharmacology (medical) Aged media_common Liver size Pharmacology biology Chemistry Hepatic cytochrome Fatty liver Organ Size Blood flow Middle Aged medicine.disease Control subjects Fatty Liver Kinetics Endocrinology Diabetes Mellitus Type 2 Pharmaceutical Preparations biology.protein Female Antipyrine Drug metabolism Research Article |
| Zdroj: | British Journal of Clinical Pharmacology. 18:895-899 |
| ISSN: | 0306-5251 |
| Popis: | The effect of fatty degeneration of liver parenchyma on drug metabolism was investigated in 21 obese non-insulin-dependent diabetic subjects by measuring plasma antipyrine kinetics, hepatic cytochrome P-450, liver size and the extent of fatty infiltration. The hepatic drug metabolising capacity, as measured by total antipyrine clearance and the estimated total amount of cytochrome P-450, was at the same level as in non-diabetic control subjects with normal livers. Relative antipyrine clearance (per unit weight of liver) and cytochrome P-450 concentrations were significantly lower in the diabetics than in controls. The extent of fatty infiltration correlated poorly with the indices of drug metabolism. In non-insulin-dependent diabetics, slight to moderate hepatic fatty infiltration, without more serious structural distortion interfering with hepatic blood flow or hepatocellular function, seems to have only a minor influence on drug metabolism. |
| Databáze: | OpenAIRE |
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