The kinetics of inflammation and phagocytosis during bovine mastitis induced by Streptococcus agalactiae bearing the protein X

Autor: Pascal Rainard, Y. Lautrou, A Coulibaly, Bernard Poutrel, Pierre Sarradin
Přispěvatelé: Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII), Institut National de la Recherche Agronomique (INRA), ProdInra, Migration
Jazyk: angličtina
Rok vydání: 1991
Předmět:
040301 veterinary sciences
medicine.drug_class
Phagocytosis
Antibiotics
Colony Count
Microbial
Cell Count
Enzyme-Linked Immunosorbent Assay
PROTEINE X
Biology
medicine.disease_cause
Streptococcus agalactiae
Microbiology
0403 veterinary science
03 medical and health sciences
Bacterial Proteins
Antigen
Streptococcal Infections
medicine
Animals
Mastitis
Bovine
Opsonin
ComputingMilieux_MISCELLANEOUS
Antigens
Bacterial
0303 health sciences
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
General Veterinary
030306 microbiology
[SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
04 agricultural and veterinary sciences
General Medicine
medicine.disease
Antibodies
Bacterial
Virology
3. Good health
Mastitis
Kinetics
Milk
Antigens
Surface
biology.protein
Cattle
Female
Antibody
Somatic cell count
Zdroj: Veterinary Research Communications
Veterinary Research Communications, Springer Verlag, 1991, 15, pp.163-176
ISSN: 0165-7380
1573-7446
Popis: The protein X of Streptococcus agalactiae is a surface antigen borne by a high proportion of strains isolated from bovine mastitis. We have tested the capacity of two strains of X-bearing Streptococcus agalactiae to induce mastitis in dairy cows. The reference X-strain (411.07) produced an intramammary infection with local clinical signs in the three inoculated quarters. Another X-bearing strain (443.31) of bovine origin produced infection in all 11 quarters inoculated with only 25 or 85 colony-forming units. In naive cows, strain 433.31 induced less exudation of plasma into the milk, shedding of bacteria, macroscopic alteration, and a lower somatic cell count (SCC) than did the reference strain. Only one quarter spontaneously eliminated the infection before antibiotic treatment 9 days after inoculation. The serum of all the cows contained naturally acquired or induced antibodies to the challenge strain (443.31) and possessed opsonic activity. Before inflammation occurred, the milk was almost devoid of antibody or opsonic activities. The early phase of infection was characterized by rapid multiplication of streptococci in the milk, followed by a sharp drop in bacterial counts concomitant with the onset of inflammation. Three cows immunized with protein X displayed higher SCC and bactericidal activity in milk from the inoculated quarter at the onset of inflammation than non-immunized cows. Two of the three immunized cows underwent an early and transient febrile episode and eliminated the infection.
Databáze: OpenAIRE
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