Evaluation of the minimal erythema dose for UVB and UVA in context of skin phototype and nature of photodermatosis

Autor: Welti, Michèle, Ramelyte, Egle, Dummer, Reinhard, Imhof, Laurence
Přispěvatelé: University of Zurich, Welti, Michèle
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
Skin type
Erythema
Ultraviolet Rays
Immunology
Photodermatosis
Skin Pigmentation
610 Medicine & health
Context (language use)
Dermatology
2708 Dermatology
Young Adult
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Reference Values
Minimal erythema dose
medicine
Humans
2741 Radiology
Nuclear Medicine and Imaging
Immunology and Allergy
Radiology
Nuclear Medicine and imaging
Medical history
Photosensitivity Disorders
Child
Aged
Retrospective Studies
Aged
80 and over
2403 Immunology
integumentary system
business.industry
10177 Dermatology Clinic
General Medicine
Middle Aged
medicine.disease
Phototype
Radiology Nuclear Medicine and imaging
030220 oncology & carcinogenesis
2723 Immunology and Allergy
Phototesting
Female
medicine.symptom
business
Zdroj: Photodermatology, Photoimmunology & Photomedicine. 36:200-207
ISSN: 1600-0781
0905-4383
DOI: 10.1111/phpp.12537
Popis: Background Phototesting is part of the standard procedure for the evaluation of patients with photosensitivity disorders. The response of patients to targeted UVB or UVA radiation helps to find out more about the nature of photodermatosis. Nevertheless, there are no default values of the minimal erythema dose (MED). Methods This study evaluated data of 203 patients (131 female, 72 male, mean age 52 years) who were referred for phototesting to the University Hospital Zurich between 2012 and 2017. We retrospectively analyzed the demographic data, medical history, skin phototype, reaction to UVB and UVA radiation, and, if present, the diagnosis of photodermatosis. In patients who did not develop erythema at the highest tested UV doses, the next logical increment was taken for analysis. In case of UVA, the two periphery doses could not be evaluated due to technical issues, so the closest reliable UVA doses were used. Results The MED‐UVB correlated with the skin type and increased with a higher phototype. No such correlation could be seen for MED‐UVA. However, the MED‐UVA was significantly reduced in patients with photodermatosis without significant differences between the subgroups of photodermatosis. More than half of the patients did not show a reduced MED despite a diagnosed photodermatosis. Conclusion We showed, how different skin types with and without photodermatosis react to UV radiation. Based on the results, we suggested threshold doses that can be chosen for phototesting, presented which doses can be considered pathologic and showed the probability of a pathologic MED in correlation with a diagnosed photodermatosis.
Databáze: OpenAIRE
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