Histones as mediators of host defense, inflammation and thrombosis
| Autor: | Hoeksema, Marloes, Eijk, Martin van, Haagsman, Henk P, Hartshorn, Kevan L, LS Moleculaire Afweer, Dep Infectieziekten Immunologie, Infection & Immunity, dI&I I&I-3 |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Extracellular Traps Inflammasomes Antimicrobial peptides Inflammation Review Biology Microbiology antimicrobial peptides 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents neutrophils Sepsis histones medicine Extracellular Animals Humans innate immunity Innate immune system Toll-Like Receptors Thrombosis Inflammasome Neutrophil extracellular traps Thrombocytopenia Immunity Innate 030104 developmental biology Histone 030220 oncology & carcinogenesis platelets biology.protein medicine.symptom medicine.drug |
| Zdroj: | Future Microbiology, 11(3), 441. Future Medicine Ltd. |
| ISSN: | 1746-0921 1746-0913 |
| DOI: | 10.2217/fmb.15.151 |
| Popis: | Histones are known for their ability to bind to and regulate expression of DNA. However, histones are also present in cytoplasm and extracellular fluids where they serve host defense functions and promote inflammatory responses. Histones are a major component of neutrophil extracellular traps that contribute to bacterial killing but also to inflammatory injury. Histones can act as antimicrobial peptides and directly kill bacteria, fungi, parasites and viruses, in vitro and in a variety of animal hosts. In addition, histones can trigger inflammatory responses in some cases acting through Toll-like receptors or inflammasome pathways. Extracellular histones mediate organ injury (lung, liver), sepsis physiology, thrombocytopenia and thrombin generation and some proteins can bind histones and reduce these potentially harmful effects. |
| Databáze: | OpenAIRE |
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