CB7 as a drug vehicle and controlled release of drug through non ionic surfactant: Spectroscopic technique
| Autor: | Subhash Chandra Bhattacharya, Swadesh Ghosh, Dipti Singharoy, Soumya Sundar Mati |
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| Rok vydání: | 2017 |
| Předmět: |
Macrocyclic Compounds
Proton Magnetic Resonance Spectroscopy Beta-Cyclodextrins 02 engineering and technology Molecular Dynamics Simulation 010402 general chemistry 01 natural sciences Micelle Surface-Active Agents Colloid and Surface Chemistry Computational chemistry Cucurbituril Organic chemistry Molecule Physical and Theoretical Chemistry Drug Carriers Molecular Structure Chemistry beta-Cyclodextrins Surfaces and Interfaces General Medicine Isoquinolines 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences Drug vehicle Nap Drug Liberation Naphthalimides Delayed-Action Preparations 0210 nano-technology Drug carrier Algorithms Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 160:84-91 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2017.09.007 |
| Popis: | A study of the comparative drug carrier properties of cucurbituril[7] (CB7) and β-cyclodextrin (β-CD) with a naphthalimide derivative, [2-(2-aminoethyl)-1H-benzo[deisoquinoline-1,3(2H)-dione] (NAP) and its release in aqueous solution using micellar environment, is the key research interest of this work. The profound changes in the different spectroscopic behavior have been attributed to the formation of a 1:1 inclusion complex for NAP:CB7 system. Several experimental outcomes clearly interpreted that CB7 has better drug carrier properties for NAP compared to β-CD. It has been also focused on the systematic release of NAP molecule from CB7 by using different ionic and non ionic surfactants. Before releasing the drug molecules from CB7 the interaction between NAP and the three different types of surfactants has also been investigated separately. The selectivity of drug carrier and releaser has been monitored, using different spectroscopic techniques like absorbance, fluorescence, fluorescence decay life time and 1 H NMR spectroscopy. Besides, a theoretical approach has been followed for a proper geometrical optimized structure of NAP molecule and molecular arrangement of NAP:CB7 inclusion complex. From Density Functional Theory (DFT) it has been seen that NAP molecule is oriented as a t-bone like structure in its optimized form. |
| Databáze: | OpenAIRE |
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