Self-reported impulsivity in Huntington's disease patients and relationship to executive dysfunction and reward responsiveness
| Autor: | Patricia L Johnson, Geoffrey F. Potts, Cynthia R Cimino, Juan Sanchez-Ramos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Punishment (psychology) Disease Impulsivity 050105 experimental psychology Developmental psychology 03 medical and health sciences Executive Function 0302 clinical medicine Huntington's disease Punishment Reward medicine Humans 0501 psychology and cognitive sciences Cognitive Dysfunction skin and connective tissue diseases Reward responsiveness 05 social sciences Dopaminergic Middle Aged medicine.disease Clinical Psychology Huntington Disease Neurology Impulsive Behavior Female sense organs Neurology (clinical) Self Report medicine.symptom Psychology 030217 neurology & neurosurgery Executive dysfunction Clinical psychology |
| Zdroj: | Journal of clinical and experimental neuropsychology. 39(7) |
| ISSN: | 1744-411X |
| Popis: | Few studies have directly investigated impulsivity in Huntington's disease (HD) despite known changes in dopaminergic and frontal functioning, changes that have been associated with impulsivity in other disorders and in the normal population. This study sought to further categorize impulsivity in HD through examining differences in self-reported impulsivity between community controls and HD patients, the relationship between executive dysfunction and impulsivity, and the relationship of a reward/punishment behavioral inhibition task in relation to these self-report measures. It was expected that HD patients would report higher impulsivity and executive dysfunction and that these measures would relate to a reward/punishment behavioral inhibition task.The Barratt Impulsivity Scale (BIS-11) and Behavioral Inhibition/Behavioral Activation Scale (BIS/BAS) were completed, and the Mini-Mental State Examination (MMSE) and a reward-based flanker task with punishing and rewarding conditions were administered to 22 HD patients and 14 control participants.HD patients reported higher trait impulsivity (BIS-11) and executive dysfunction (Frontal Systems Behavior Scale, FrSBE) but not increased impulsivity on the BIS/BAS relative to controls. Higher BIS-11 scores were related to increased self-reported executive dysfunction and the attention/working memory factor of the MMSE. On a reward/punishment behavioral inhibition task, BAS was uniquely related to increased accuracy on rewarding trials of the flanker task, but was not related to punishing trials in HD patients.The relationships found suggest that trait impulsivity is reported higher in HD and may not be driven by altered reward evaluation and the appetitive nature of stimuli but rather by increased executive dysfunction and lack of sensitivity to punishment. Impulsivity in HD may represent a combination of trait impulsivity, altered dopaminergic circuitry, and executive dysfunction. Understanding impulsivity in HD is important as it is related to increased risk to the patient and difficult behaviors for the caregiver, and sheds light on the disease process. |
| Databáze: | OpenAIRE |
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