IL-37 Gene and Cholesterol Metabolism: Association of Polymorphisms with the Presence of Hypercholesterolemia and Cardiovascular Risk Factors. The GEA Mexican Study
| Autor: | José Manuel Fragoso, José Manuel Rodríguez-Pérez, Rosalinda Posadas-Sánchez, Gilberto Vargas-Alarcón, Christian Vázquez-Vázquez, Fabiola López-Bautista |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male cardiovascular risk factors medicine.medical_specialty medicine.medical_treatment Cardiovascular risk factors lcsh:QR1-502 Inflammation Logistic regression Biochemistry Article lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Medicine Humans Molecular Biology Gene Mexico Polymorphism Genetic Models Genetic hypercholesterolemia business.industry Confounding Interleukin Middle Aged 030104 developmental biology Endocrinology Cytokine Cardiovascular Diseases inflammation Cohort Female medicine.symptom business polymorphisms interleukin 37 030215 immunology Interleukin-1 |
| Zdroj: | Biomolecules, Vol 10, Iss 1409, p 1409 (2020) Biomolecules Volume 10 Issue 10 |
| Popis: | Interleukin 37 (IL-37) is an anti-inflammatory cytokine involved in the regulation of cholesterol homeostasis, reducing the levels of plasma cholesterol, fatty acids, and triglycerides. The aim of the present study was to evaluate the association of the IL-37 polymorphisms with the presence of hypercholesterolemia (HC), and with cardiovascular risk factors. Nine IL-37 polymorphisms (rs2708965, rs2708962, rs6717710, rs2708961, rs2708960, rs2708958, rs2723187, rs2708947, and rs2723192) were determined by TaqMan assays in a group of 1292 individuals (514 with and 778 without hypercholesterolemia) belonging to the cohort of the GEA Mexican Study. The associations were evaluated by logistic regression, using inheritance models adjusted by confounding variables. Under codominant 1 model, the rs2708961 (OR = 0.51, p = 0.02), rs2723187 (OR = 0.35, p = 0.005), and rs2708947 (OR = 0.49, p = 0.02) polymorphisms were associated with low risk of HC. The association of the polymorphisms with cardiovascular risk factors was evaluated independently in HC and non-HC individuals. In non-HC individuals, some polymorphisms were associated with the risk of having high levels of LDL-C, glucose, and high risk of T2DM, and low risk of having high visceral abdominal fat. On the other hand, in individuals with HC five, polymorphisms were associated with high levels of C-reactive protein. The IL-37 rs2708961, rs2723187, rs2708947 polymorphisms were associated with low risk of HC, and some IL-37 polymorphisms were associated with cardiometabolic factors in both individuals with and without HC. |
| Databáze: | OpenAIRE |
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