Direct observations of the metal-ligand bifunctional addition step in an enantioselective ketone hydrogenation

Autor:	Steven H. Bergens, Robin J. Hamilton
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Addition reaction Ketone Enantioselective synthesis General Chemistry Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound Colloid and Surface Chemistry chemistry Alkoxide Organic chemistry Bifunctional Racemization Acetophenone
Zdroj:	Journal of the American Chemical Society. 130(36)
ISSN:	1520-5126
Popis:	The catalytic intermediate trans-[Ru((R)-BINAP)(H)2((R,R)-dpen)] (1) reacted on mixing with acetophenone in THF at -80 degrees C under approximately 2 atm H2 to generate the alkoxide trans-Ru((R)-BINAP)(H)((Ph)(Me)CHO)((R,R)-dpen) (6). Contrary to expectations, free Ru-amide and 1-phenylethanol were not the immediate products of this addition reaction. The addition reaction was reversible in THF. 2-Propanol prevents racemization of the alcohol product in THF solvent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a530130237675f3757764f2b6aa793e https://pubmed.ncbi.nlm.nih.gov/18702465 Zobrazit plný text záznamu