Oestrogen, Progestogen and Liver-Function Tests
| Autor: | Arvo Heino, Antti Eisalo, Veikko Räsänen |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.drug_class medicine.medical_treatment Ethinyl Estradiol Lynestrenol Sulfobromophthalein Transaminase Liver Function Tests Pregnancy Internal medicine Methods medicine Humans Transaminases Aged biology Progestogen business.industry Mestranol Obstetrics and Gynecology Bilirubin Drug Synergism Estrogens Megestrol General Medicine Middle Aged Alkaline Phosphatase Thymol Cholesterol Endocrinology Liver Alanine transaminase Estrogen Megestrol acetate Prothrombin Time biology.protein Female Progestins business Progestin Contraceptives Oral medicine.drug |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 47:58-65 |
| ISSN: | 1600-0412 0001-6349 |
| DOI: | 10.3109/00016346809157466 |
| Popis: | Liver-function tests were studied in 40 postmenopausal women receiving synthetic steroids. 10 received .15 mg mestranol daily 10 received 5 mg lynestrenol 10 received .05 mg 17alpha-ethinyl estradiol and 10 received 4 mg megestrol acetate daily. In the 2nd phase of the test the estrogen groups had the progestin compound added and the progestin group had the estrogen added. However 4 serious thromboembolic phenomena during this phase and therapy was discontinued. The subjects were aged 52-78 years and used no drugs known to produce intrahepatic cholestasis. Laboratory tests included serum total bilirubin thymol turbidity alkaline phosphatase serum asp artate transaminase serum alanine transaminase serum cholesterol prothrombin index and bromsulphthalein retention (BSP). All tests were normal with ethinyl estradiol; 1 of the 10 showed slight BSP retention increase when megestrol acetate was added. In 5 of 9 treated with mestranol there developed increased BSP and in 1 of this group elevated serum transaminases levels occurred. 8 of the 10 lynestrenol women showed increased BSP retention. When treatment was continued with the combination of lynestrenol-mestranol BSP retention increased still further in the 4 of 6 women still in the study and in this group serum transaminases were most clearly elevated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|