Persistent metabolic changes in HIV-infected patients during the first year of combination antiretroviral therapy
| Autor: | Jörgen Bierau, Annelies Verbon, Jun Hou, Amy C. Harms, Jaap A. Bakker, Thomas Hankemeier, Andre Boonstra, Johannes C. Schoeman, N. Chantal Peltenburg, Fernando Mora, Selwyn H. Lowe |
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| Přispěvatelé: | Internal Medicine, Medical Microbiology & Infectious Diseases, Gastroenterology & Hepatology, Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA MMI Staf (9), MUMC+: DA KG Lab Centraal Lab (9), RS: CAPHRI - R4 - Health Inequities and Societal Participation |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cart Adult Male EXPRESSION Biogenic Amines lcsh:Medicine HIV Infections Disease INNATE ACQUIRED-IMMUNODEFICIENCY-SYNDROME Article DISEASE Cohort Studies 03 medical and health sciences Immune system SDG 3 - Good Health and Well-being Antiretroviral Therapy Highly Active Hiv infected patients Medicine Humans Metabolomics Lymphocyte Count lcsh:Science Multidisciplinary ROLES business.industry INTERLEUKIN-18 lcsh:R virus diseases Middle Aged Antiretroviral therapy Lipids 030104 developmental biology Anti-Retroviral Agents Immunology Cohort Host-Pathogen Interactions CELLS HIV-1 RISK-FACTORS Interleukin 18 lcsh:Q Female business C VIRUS-INFECTION Biomarkers Cohort study |
| Zdroj: | Scientific Reports, 8 Scientific Reports, 8, 16947 Scientific Reports, 8:16947. Nature Publishing Group Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) |
| ISSN: | 2045-2322 |
| Popis: | The HIV-human metabolic relationship is a complex interaction convoluted even more by antiretroviral therapy (cART) and comorbidities. The ability of cART to undo the HIV induced metabolic dysregulation is unclear and under-investigated. Using targeted metabolomics and multiplex immune biomarker analysis, we characterized plasma samples obtained from 18 untreated HIV-1-infected adult patients and compared these to a non-HIV infected (n = 23) control population. The biogenic amine perturbations during an untreated HIV infection implicated altered tryptophan- nitrogen- and muscle metabolism. Furthermore, the lipid profiles of untreated patients were also significantly altered compared to controls. In untreated HIV infection, the sphingomyelins and phospholipids correlated negatively to markers of infection IP-10 and sIL-2R whereas a strong association was found between triglycerides and MCP-1. In a second cohort, we characterized plasma samples obtained from 28 HIV-1-infected adult patients before and 12 months after the start of cART, to investigate the immune-metabolic changes associated with cART. The identified altered immune-metabolic pathways of an untreated HIV infection showed minimal change after 12 months of cART. In conclusion, 12 months of cART impacts only mildly on the metabolic dysregulation underlying an untreated HIV infection and provide insights into the comorbidities present in virally suppressed HIV patients. |
| Databáze: | OpenAIRE |
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