1-methyl-1,4-androstadiene-3,17-dione (SH 489): Characterization of an irreversible inhibitor of estrogen biosynthesis
| Autor: | David Dr Henderson, G. Norbisrath, Ulrich Kerb |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Drug
Placenta media_common.quotation_subject In Vitro Techniques Pharmacology Biochemistry Structure-Activity Relationship Endocrinology Atamestane Pregnancy Microsomes medicine Humans Aromatase Estrogen biosynthesis media_common biology Aromatase Inhibitors Chemistry Androstenedione Kinetics biology.protein Female Oxidation-Reduction medicine.drug |
| Zdroj: | Journal of Steroid Biochemistry. 24:303-306 |
| ISSN: | 0022-4731 |
| DOI: | 10.1016/0022-4731(86)90069-5 |
| Popis: | 1-Methyl-1,4-androstadiene-3,17-dione (SH 489) was characterized as a competitive and irreversible inhibitor of human placental aromatase. The compound and the principal predicted metabolites show no endocrinological side effects suggesting that SH 489 should be suitable as a prototype drug for treatment of estrogen-dependent disease states. |
| Databáze: | OpenAIRE |
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