Amplification of N-myc gene and increase of urinary VMA and HVA in patients with neuroblastic tumors
| Autor: | Tasuku Shoji, Yoshitaka Fukunaga, Nobuo Nomura, Masao Yamamoto, Koho Akimaru, Ryotaro Ishizaki |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Urinary system Nervous System Neoplasms Genes myc Gastroenterology Asymptomatic Neuroblastoma Vanilmandelic Acid Internal medicine medicine Humans Survival rate Mass screening Neoplasm Staging Ganglioneuroblastoma Ganglia Sympathetic business.industry Adrenal gland Gene Amplification Infant Homovanillic Acid General Medicine Prognosis medicine.disease Neuroblastic Tumor medicine.anatomical_structure Child Preschool Cancer research Female medicine.symptom business |
| Zdroj: | Journal of Nippon Medical School. 61:148-153 |
| ISSN: | 1884-0108 0048-0444 |
| DOI: | 10.1272/jnms1923.61.148 |
| Popis: | Neuroblastic tumor cases in our departments were evaluated in terms of the stage of the tumor, N-myc amplification, urinary vanillylamndelic acid (VMA)/homovanillic acid (HVA) and survival rate. Two asymptomatic cases, diagnosed when under a year old by mass screening, had no amplifications of N-myc but showed more than one value of urinary VMA/HVA ratio. The patients are now doing well eight years after complete excision of the neuroblastoma which had originated in the sympathetic ganglion. On the other hand, two other symptomatic cases, operated on at the ages of 3 and 5 years, showed remarkable amplifications with less than one value of urinary VMA/HVA, and died from the tumor soon after partial resection of the neuroblastoma and ganglioneuroblastoma which had originated in the adrenal gland and the sympathetic ganglion, respectively. The present monograph reports our cases and discusses prognostic factors. |
| Databáze: | OpenAIRE |
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