Evidence of an increased nitric oxide production in primary biliary cirrhosis
| Autor: | Gianpaolo Molino, Floriano Rosina, Giuseppe Poli, G. Cavalli, F. Bar, Ezio David, Stefania Battista, B Cavalieri, Juan Carlos Cutrin, Giulio Mengozzi, Cristina Pollet, Mauro Torchio |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Liver Cirrhosis Male Alcoholic liver disease medicine.medical_specialty Cirrhosis Biliary cirrhosis Inflammation Nitric Oxide Nitric oxide chemistry.chemical_compound Primary biliary cirrhosis Liver Cirrhosis Alcoholic Internal medicine medicine Humans primary biliary cirrhosis nitric oxide Aged Aged 80 and over Hepatology biology Liver Cirrhosis Biliary business.industry Elastase Gastroenterology Middle Aged Intercellular Adhesion Molecule-1 medicine.disease Endocrinology Solubility chemistry Virus Diseases Neutrophil elastase biology.protein Female medicine.symptom E-Selectin Leukocyte Elastase business |
| Zdroj: | The American Journal of Gastroenterology. 96:869-875 |
| ISSN: | 1572-0241 0002-9270 |
| Popis: | Although possible implications of nitric oxide in the pathophysiology of liver cirrhosis have been extensively studied, until now few articles have addressed the assessment of nitric oxide production in primary biliary cirrhosis. This study was directed to evaluate circulating nitrosyl-hemoglobin levels as well as neutrophil elastase and soluble adhesion molecule concentrations in this condition, by assuming these parameters as possible markers of either inflammatory response or neutrophil activation.Laboratory investigations were performed in 30 patients with primary biliary cirrhosis, in 13 patients with postviral and/or alcoholic cirrhosis, and in a group of eight subjects with chronic hepatitis.Although no difference was detected with respect to chronic hepatitis subjects, higher levels of nitrosyl-hemoglobin adducts were found in primary biliary cirrhosis patients than in postviral or alcoholic cirrhotics and in normal subjects (3.55+/-1.75 arbitrary units vs 1.95+/-0.57 and 0.84+/-0.34, p = 0.0004 and p0.0001, respectively). Similarly, more elevated concentrations of neutrophil elastase (213.7+/-192.0 microg/L vs 51.1+/-34.3 and 38.0+/-11.5, p0.0001 and p0.0001, respectively) as well as of soluble forms of intercellular adhesion molecule 1 and endothelial-leukocyte adhesion molecule 1 were shown in primary biliary cirrhosis patients than in subjects with cirrhosis of other etiologies and in controls.Highly enhanced nitric oxide production in primary biliary cirrhosis could be related to the development of strong inflammation and at least partially to neutrophil activation, thus suggesting a putative role of these cellular mediators in the development of liver damage owing to their ability to synthesize and release a wide variety of important factors, including elastase and nitric oxide. |
| Databáze: | OpenAIRE |
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