Development of an Orally Active Small-Molecule Inhibitor of Receptor Activator of Nuclear Factor-κB Ligand

Autor:	Kai Yang, Shunyao Li, Tianqi Wang, Xueming Yan, Qian He, Ruonan Ning, Xing Xu, Wei Yao, Xiaofei Zhang, Chunhao Yang, Min Jiang, Lianfu Deng
Rok vydání:	2022
Předmět:	Mice Receptor Activator of Nuclear Factor-kappa B Drug Discovery RANK Ligand NF-kappa B Molecular Medicine Animals Osteoclasts Cell Differentiation Bone Resorption Ligands
Zdroj:	Journal of medicinal chemistry. 65(16)
ISSN:	1520-4804
Popis:	Receptor activator of nuclear factor-κB (RANK) and its ligand, RANKL, play pivotal roles in bone remodeling. The monoclonal antibody denosumab successfully inhibited the maturation of osteoclasts (OCs) by binding to RANKL in the clinic. We continued our efforts to develop small-molecule inhibitors of RANKL. In this work, 41 β-carboline derivatives were synthesized based on previously synthesized compound
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4614aefd2ebd65fd5ace4bde350067 https://pubmed.ncbi.nlm.nih.gov/35960655 Zobrazit plný text záznamu