Alpha-Fetoprotein-Producing Extrahepatic Tumor: Clinical and Histopathological Significance of a Case
| Autor: | Jose A. Nuevo-Gonzalez, Juan A. Andueza-Lillo, Beatriz Lopez, Luis Audibert, Juan Carlos Cano-Ballesteros |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Anemia medicine.medical_treatment Adenocarcinoma Gastroenterology Gastrectomy Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Humans Aged Chemotherapy business.industry Stomach Liver Neoplasms digestive oral and skin physiology Histology Prognosis medicine.disease Combined Modality Therapy digestive system diseases Radiation therapy medicine.anatomical_structure Oncology Female alpha-Fetoproteins Tomography X-Ray Computed Alpha-fetoprotein business |
| Zdroj: | Journal of Gastrointestinal Cancer. 43:28-31 |
| ISSN: | 1941-6636 1941-6628 |
| DOI: | 10.1007/s12029-011-9310-0 |
| Popis: | The serum rise of alpha-fetoprotein (AFP) has been relationed to hepatic tumors. Other than these, such as gastric adenocarcinoma, can present with high levels of this glycoprotein. One rare kind of gastric adenocarcinoma, called hepatoid subtype, has two essential features: hepatoid differentiation in histology and high levels of AFP in serum. We report a Spanish female who consulted because of fatigue, anorexia, and weight loss. In laboratory data, she presented anemia and markedly elevation of AFP. On CT scan, a gastric mass resulted without hepatic dissemination, and subsequently, gastroduodenoscopy was performed for histological diagnosis. Then, an ulcerated mass was detected and sample was taken, resulting in poorly-differentiated adenocarcinoma of stomach with hepatoid tissue foci, with intense positivity for AFP-immunohistochemical staining. This rare cancer has poor prognosis even with early gastrectomy and chemotherapy. |
| Databáze: | OpenAIRE |
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