Applications of laser-polarized 129Xe to biomolecular assays
| Autor: | Seth M. Rubin, Peter G. Schultz, E. Janette Ruiz, Alexander Pines, Nicolas Winssinger, Megan M. Spence, Thomas J. Lowery, David E. Wemmer |
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| Rok vydání: | 2004 |
| Předmět: |
Chemistry
Protein Conformation Lasers Biomedical Engineering Biophysics Analytical chemistry technology industry and agriculture Nanotechnology Xenon binding macromolecular substances Laser Ligand-protein interactions Ligands law.invention Signal enhancement law Humans Xenon Isotopes Radiology Nuclear Medicine and imaging Protein conformation assay Biological imaging Biosensor Nuclear Magnetic Resonance Biomolecular Preclinical imaging |
| Zdroj: | Magnetic Resonance Imaging, Vol. 21, No 10 (2003) pp. 1235-1239 |
| ISSN: | 0730-725X |
| Popis: | The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and functionalized 129Xe NMR to in vitro biomolecular assays suggests the potential future use of a functionalized xenon biosensor for in vivo imaging. |
| Databáze: | OpenAIRE |
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