Myoclonic status epilepticus as a presentation of caspr2 antibody-associated autoimmune encephalitis
| Autor: | Andrew Bleasel, Zebunnessa Rahman, David A. Fulcher, Russell C. Dale, Sudarshini Ramanathan, Chong H. Wong |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Cyclophosphamide Epilepsies Myoclonic Nerve Tissue Proteins Status epilepticus Hashimoto Disease Diagnosis Differential Status Epilepticus Prednisone medicine Humans Autoantibodies Autoimmune encephalitis Brain Diseases business.industry Autoantibody Membrane Proteins Electroencephalography General Medicine medicine.disease Early Diagnosis Neurology Immunology Encephalitis Rituximab Female Neurology (clinical) medicine.symptom Differential diagnosis business medicine.drug |
| Zdroj: | Epileptic disorders : international epilepsy journal with videotape. 16(4) |
| ISSN: | 1294-9361 |
| Popis: | We present a case of autoimmune encephalitis associated with antibodies targeting contact in-associated protein-like 2. This case is notable because of the presentation with myoclonic status epilepticus and the prolonged clinical course of refractory seizures, which are demonstrated in the accompanying videos, and not previously associated with this condition. Treatment with prednisone, intravenous immunoglobulin, plasma exchange, rituximab, cyclophosphamide, and mycophenolate mofetil resulted in significant functional improvement. Historically, myoclonic status epilepticus is associated with a grave prognosis and minimal chance of meaningful recovery. This case demonstrates that autoimmune encephalitis remains an important differential diagnosis in patients with such a presentation, and that early recognition and the appropriate institution of immunotherapy can result in seizure control and functional recovery. [Published with video sequences]. |
| Databáze: | OpenAIRE |
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