Induction of hair growth by implantation of cultured dermal papilla cells
| Autor: | Colin A.B. Jahoda, Kenneth A. Horne, R. F. Oliver |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Cellular differentiation Population Connective tissue Matrix (biology) Biology Internal medicine medicine Animals education Cells Cultured education.field_of_study Multidisciplinary integumentary system Epidermis (botany) Cell Differentiation Fibroblasts Cell biology Rats Transplantation Major duodenal papilla medicine.anatomical_structure Endocrinology Dermal papillae Epidermal Cells Vibrissae Hair |
| Zdroj: | Nature. 311(5986) |
| ISSN: | 0028-0836 |
| Popis: | Mammalian hairs are formed by differentiation and keratinization of cells produced in the epidermal matrix (Figs 3, 4). Using the rodent vibrissa follicle as a model1, transplantation studies have shown that the dermal papilla, a discrete population of specialized fibroblasts, is of prime importance in the growth of hair2,3. Papillae induce hair growth when implanted into follicles4,5 and can interact with skin epidermis to form new hair follicles6. When grown in culture, papilla cells display singular morphological and behavioural characteristics compared with connective tissue cells from other skin sources7,8. We report here that serially cultured adult papilla cells can induce the growth of hair when implanted into follicles which otherwise would not grow hairs. This finding presents an opportunity to characterize properties distinguishing the papilla cell population from other skin fibroblasts, and, more specifically, those which control hair growth. The eventual application of this work to human hair replacement techniques can also be envisaged. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|