Effects of losartan on hypertension and left ventricular mass: a long-term study
| Autor: | Diana Iarussi, Domenico Galzerano, Giuseppe Limongelli, Aldo Iacono, M A Tedesco, G. Di Salvo, D Aquino, Gennaro Ratti, S. Mennella |
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| Přispěvatelé: | Tedesco, Ma, Ratti, G, Aquino, D, Caccavale, A, Limongelli, Giuseppe, DI SALVO, Giovanni |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Left ventricular ma Diastole Angiotensin II receptor antagonist Essential hypertension Losartan Left ventricular mass Hydrochlorothiazide Double-Blind Method Internal medicine Internal Medicine Humans Medicine Antihypertensive Agents Aged business.industry Female Hypertension Hypertrophy Left Ventricular Middle Aged Hypertrophy medicine.disease Left Ventricular Surgery Blood pressure Tolerability Blood chemistry Cardiology business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/sj.jhh.1000685 |
| Popis: | This study evaluated the anti-hypertensive efficacy, tolerability and effects on left ventricular mass of losartan, a selective angiotensin II receptor antagonist, after 22 months in patients with essential hypertension. The study included 77 hypertensive patients who were randomised at baseline to 22 months double-blind once-daily treatment with losartan 50 mg (L group n = 44 patients, mean age 54+/-9 years) or hydrochlorothiazide 25 mg (HCTZ group, n = 33 patients, mean age 56+/-7 years). Routine haematology, blood chemistry, standard electrocardiography, echocardiography and ambulatory non-invasive 24-h blood pressure (BP) monitoring were performed at baseline and after 10 and 22 months. The results showed good tolerability and a significant mean systolic and diastolic BP reduction in all groups (L group: 22 mm Hg and 11 mm Hg; HCTZ group: 11 mm Hg and 7 mm Hg, respectively for systolic and diastolic mean BP). Moreover, a remarkable reduction in left ventricular mass index was reached after 10 and 22 months only in the L group (L group: delta = -11 g/m2, P |
| Databáze: | OpenAIRE |
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