Oncofetal antigen expression in head and neck carcinoma
| Autor: | Gerald S. Gussack |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.drug_class Cell Cell Separation medicine.disease_cause Monoclonal antibody Proto-Oncogene Mas Flow cytometry Cell Line Immunoenzyme Techniques Antigen Antigens Neoplasm medicine Tumor Cells Cultured Humans medicine.diagnostic_test business.industry DNA Neoplasm Flow Cytometry stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Cell culture Head and Neck Neoplasms Carcinoma Squamous Cell Immunohistochemistry business Carcinogenesis Oncofetal antigen |
| Zdroj: | The Laryngoscope. 102(2) |
| ISSN: | 0023-852X |
| Popis: | Oncofetal antigens (OFA) are proteins expressed during periods of embryonal/fetal development and on malignant cells. Previous investigations detected the presence of phase-specific 44-and 200-kd OFA, using a monoclonal antibody (MoAb 115). This study will determine if primary head and neck squamous cell carcinomas express the 44-kd OFA, and will assess the possible role of OFA in oncogenesis. Fifteen primary human head and neck squamous cell carcinomas (HNSCC) and six HNSCC cell lines were tested for OFA expression. Thirteen primary cancers and three cell lines demonstrated various degrees of OFA positivity. Oncofetal antigens are proposed to represent a proto-oncogene active during fetal development and malignant growth in head and neck squamous cell carcinomas. |
| Databáze: | OpenAIRE |
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