Supplementary Data from LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti–PD-1 Therapy against Brain Tumors

Autor: Nobuyuki Takakura, Haruhiko Kishima, Kazuhiro Takara, Yasunori Fujimoto, Naoki Kagawa, Hideyuki Arita, Hiroyasu Kidoya, Fumitaka Muramatsu, Taku Wakabayashi, Tomohiro Iba, Yonehiro Kanemura, Hisamichi Naito, Yohei Tsukada, Daisuke Eino
Rok vydání: 2023
DOI: 10.1158/0008-5472.22418390.v1
Popis: Supplementary Figure 1. Coverage of pericyte and the basal membrane by LPA. Expression of LPA4 in several tumors. Supplementary Figure 2. Survival of wild-type and LPA4-KO mice harboring LLC brain tumors treated with or without LPA in the presence or absence of 5-FU. Supplementary Figure 3. Junctional protein expressioon in vascular endothelial cells by LPA. Supplementary Figure 4. LPA induces ICAM-1 expression but doesn't alter the expression of an HEV marker protein on endothelial cells Supplementary Figure 5. Investigation of LPA mediated VCAM-1 expression in MS-1 cells by using several inhibitors. Supplementary Figure 6. PD-L1 expression in GL261 brain tumors and LLC subcutaneous tumors. HE staining of the brain after anti-PD-1 antibody and LPA treatment.
Databáze: OpenAIRE