| Autor: |
Juanjuan Zhao, Chengyu Liu, Fenyan Zhang, Ziyi Zheng, Fenlan Luo, Jianxia Xia, Yaling Wang, Zehui Zhang, Jinxiang Tang, Zhenbo Song, Siyu Li, Kan Xu, Mengting Chen, Chenggang Jiang, Chao He, Ling Tang, Zhian Hu, Dong Gao, Shuancheng Ren |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cell Reports. 41:111824 |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2022.111824 |
| Popis: |
Heightened wakefulness in response to stressors is essential for survival but can also lead to sleep disorders like insomnia. The paraventricular thalamus (PVT) is both a critical thalamic area for wakefulness and a stress-sensitive brain region. However, whether the PVT and its neural circuitries are involved in controlling wakefulness in stress conditions remains unknown. Here, we find that PVT neurons projecting to the central amygdala (CeA) are activated by different stressors. These neurons are wakefulness-active and increase their activities upon sleep to wakefulness transitions. Optogenetic activation of the PVT-CeA circuit evokes transitions from sleep to wakefulness, whereas selectively silencing the activity of this circuit decreases time spent in wakefulness. Specifically, chemogenetic inhibition of CeA-projecting PVT neurons not only alleviates stress responses but also attenuates the acute stress-induced increase of wakefulness. Thus, our results demonstrate that the PVT-CeA circuit controls physiological wakefulness and modulates acute stress-induced heightened wakefulness. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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