Metabolism of aromatic amino acids in collagen diseases: urinary excretion of 3-methoxy-4-hydroxymandelic acid and the interference of 3-methoxy-4-hydroxyphenylpyruvate
| Autor: | Nicholas Matsaniotis, N.S. Constantsas, K.B. Choremis, Anthony Agathopoulos, C. Danelatos-Athanassiadis |
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| Rok vydání: | 1967 |
| Předmět: |
Monoamine oxidase
Chromatography Paper Phenylpyruvic Acids Urinary system Clinical Biochemistry In Vitro Techniques Biochemistry Excretion chemistry.chemical_compound In vivo Aromatic amino acids Humans Child Monoamine Oxidase 4-hydroxyphenylpyruvate 4-hydroxymandelic acid Chemistry Biochemistry (medical) Periodic Acid Collagen Diseases General Medicine Metabolism Spectrophotometry Chemistry Clinical Child Preschool Mandelic Acids Rheumatic Fever |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 17(1) |
| ISSN: | 0009-8981 |
| Popis: | Urinary 3-methoxy-4-hydroxymandelic acid was low in 19 children with rheumatic fever and other collagen diseases as compared to 16 controls; its immediate precursors, the meta-catecholamines, were low too, though in a less pronounced way. The excretion of 3-methoxy-4-hydroxymandelic acid was plotted against that of meta-catecholamines; the results suggest decreased monoamine oxidase activity in the patients. Evidence is also presented that 3-methoxy-4-hydroxyphenylpyruvate cannot be transformed spontaneously to 3-methoxy-4-hydroxymandelate. This latter seems to be produced exclusively by the enzymic transformation of meta-catecholamines in vivo . |
| Databáze: | OpenAIRE |
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