Transapical mitral valve implantation for treatment of symptomatic mitral valve disease: a real-world multicentre experience
| Autor: | Wild, Mirjam G, Kreidel, Felix, Hell, Michaela M, Praz, Fabien, Mach, Markus, Adam, Matti, Reineke, David, Ruge, Hendrik, Ludwig, Sebastian, Conradi, Lenard, Rudolph, Tanja K, Bleiziffer, Sabine, Kellermair, Jörg, Zierer, Andreas, Nickenig, Georg, Weber, Marcel, Petronio, Anna Sonia, Giannini, Cristina, Dahle, Gry, Rein, Kjell A, Coisne, Augustin, Vincentelli, André, Dubois, Christophe, Duncan, Alison, Quarto, Cesare, Unbehaun, Axel, Amat-Santos, Ignacio, Cobiella, Javier, Dumonteil, Nicolas, Estevez-Loureiro, Rodrigo, Fumero, Andrea, Geisler, Tobias, Lurz, Philipp, Mangieri, Antonio, Monivas, Vanessa, Noack, Thilo, Franco, Luis Nombela, Pinon, Miguel A, Stolz, Lukas, Tchétché, Didier, Walter, Thomas, Unsöld, Bernhard, Baldus, Stephan, Andreas, Martin, Hausleiter, Jörg, von Bardeleben, Ralph S |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Cardiac Catheterization Cardiac & Cardiovascular Systems FEASIBILITY Heart Valve Diseases 610 Medicine & health REGURGITATION PROSTHESIS Tendyne Humans Mitral regurgitation Aged Retrospective Studies REPAIR Aged 80 and over Heart Failure Heart Valve Prosthesis Implantation OUTCOMES Science & Technology Mitral Valve Insufficiency REPLACEMENT Treatment Outcome Mitral valve disease Heart Valve Prosthesis Cardiovascular System & Cardiology Mitral Valve Female Cardiology and Cardiovascular Medicine Life Sciences & Biomedicine Transcatheter mitral valve implantation |
| Zdroj: | Wild, Mirjam G; Kreidel, Felix; Hell, Michaela M; Praz, Fabien; Mach, Markus; Adam, Matti; Reineke, David; Ruge, Hendrik; Ludwig, Sebastian; Conradi, Lenard; Rudolph, Tanja K; Bleiziffer, Sabine; Kellermair, Jörg; Zierer, Andreas; Nickenig, Georg; Weber, Marcel; Petronio, Anna Sonia; Giannini, Cristina; Dahle, Gry; Rein, Kjell A; ... (2022). Transapical mitral valve implantation for treatment of symptomatic mitral valve disease: a real-world multicentre experience. European journal of heart failure, 24(5), pp. 899-907. Wiley 10.1002/ejhf.2434 |
| DOI: | 10.1002/ejhf.2434 |
| Popis: | AIMS: Transcatheter mitral valve implantation (TMVI) is a new treatment option for patients with symptomatic mitral valve (MV) disease. Real-world data have not yet been reported. This study aimed to assess procedural and 30-day outcomes of TMVI in a real-world patient cohort. METHOD AND RESULTS: All consecutive patients undergoing implantation of a transapically delivered self-expanding valve at 26 European centres from January 2020 to April 2021 were included in this retrospective observational registry. Among 108 surgical high-risk patients included (43% female, mean age 75 ± 7 years, mean STS-PROM 7.2 ± 5.3%), 25% was treated for an off-label indication (e.g. previous MV intervention or surgery, mitral stenosis, mitral annular calcification). Patients were highly symptomatic (New York Heart Association [NYHA] functional class III/IV in 86%) and mitral regurgitation (MR) was graded 3+/4+ in 95% (38% primary, 37% secondary, and 25% mixed aetiology). Technical success rate was 96%, and MR reduction to ≤1+ was achieved in all patients with successful implantation. There were two procedural deaths and 30-day all-cause mortality was 12%. At early clinical follow-up, MR reduction was sustained and there were significant reductions of pulmonary pressure (systolic pulmonary artery pressure 52 vs. 42 mmHg, p |
| Databáze: | OpenAIRE |
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