Study of the influence of autoclave sterilization on the properties of citrate functionalized iron oxide nanoparticles
| Autor: | Franck Cleymand, Solenne Fleutot, Astrid Pinzano, Thomas Girardet, Amel Cherraj, Christel Henrionnet |
|---|---|
| Přispěvatelé: | Institut Jean Lamour (IJL), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
synthesis
Chemistry General Chemical Engineering iron oxide nanoparticles sterilization 02 engineering and technology General Chemistry physicochemical properties Sterilization (microbiology) 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Autoclave chemistry.chemical_compound Chemical engineering Surface modification functionalization [CHIM]Chemical Sciences magnetic properties 0210 nano-technology Iron oxide nanoparticles |
| Zdroj: | Pure and Applied Chemistry Pure and Applied Chemistry, De Gruyter, 2021, pp.000010151520210303. ⟨10.1515/pac-2021-0303⟩ |
| ISSN: | 0033-4545 1365-3075 |
| DOI: | 10.1515/pac-2021-0303⟩ |
| Popis: | Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are widely used in various areas of the biomedical field: for diagnosis (Magnetic Resonance Imaging), for therapeutic applications (hyperthermia, nanovectorization). These applications require a good stability in water and no aggregation of SPIONs, with well-controlled physicochemical and magnetic properties. In this work, SPIONs functionalized by citrate ligands are synthesized in a one-step process with the aim of producing stable water-dispersible nanoparticles with a well-crystallized spinel structure. Microwave technology is implemented to achieve this objective given the ease, speed and reproducibility of the method. For their future use in biomedical applications, the sterilization of these SPIONs are essential by an autoclave treatment. The influence of this treatment on the physicochemical and magnetic properties of the SPIONs is determined by a systematic characterization before and after sterilization by Transmission Electronic Microscopy, Dynamic Light Scattering, X-ray Diffraction, Fourier Transformed Infra-Red, ThermoGravimetric Analysis and magnetic measurements. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|