A facile and efficient method for the synthesis of crystalline tetrahydro-β-carbolines via the Pictet-Spengler reaction in water

Autor:	Gi-Seong Moon, Kyung-Hwan Jung, Sung-Kwon Moon, Hyang-Yeol Lee, Hong-Ju Byeon
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Tryptamine Multidisciplinary Pictet–Spengler reaction Cancer therapy 010405 organic chemistry Natural compound Biological techniques lcsh:R lcsh:Medicine One-Step 010402 general chemistry 01 natural sciences Environmentally friendly Article 0104 chemical sciences Solvent chemistry.chemical_compound chemistry Organic chemistry Drug discovery and development lcsh:Q Tryptoline Cytotoxicity lcsh:Science
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020) Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-020-57911-0
Popis:	A facile and efficient synthesis of tetrahydro-β-carbolines (tryptolines) in one step from tryptamine and aldehydes, in an environmentally friendly water solvent, has been investigated. This convenient and clean synthesis of various tryptolines was facilitated by l-tartaric acid, a natural compound, to obtain the desired products as clear crystals. Among the four crystalline products, the most substituted tryptoline 2 showed the best inhibitory activity against EJ cells and the least cytotoxicity, with an LC50 value of 1.49 mg/mL, against brine shrimp larvae.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3686c72336c41158ee0be40eb80c4c http://link.springer.com/article/10.1038/s41598-020-57911-0 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.