The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation

Autor:	James J. S. Treanor, Brad Youngblood, Jean-Claude Louis, Mark H. Norman, April Le, Lana Klionsky, Bora Han, Dawn Zhu, Sekhar Surapaneni, Anu Gore, Jue Wang, Rongzhen Kuang, Rami Tamir, Hong Deng, David N. Hovland, Ella Magal, Anthony W. Bannon, Narender R. Gavva, Todd Juan, Sonya G. Lehto
Rok vydání:	2007
Předmět:	Hyperthermia Male Fever TRPV1 TRPV Cation Channels CHO Cells Hypothermia Pharmacology TRPV Rats Sprague-Dawley Transient receptor potential channel chemistry.chemical_compound Cricetulus Dogs Species Specificity Cricetinae Quinoxalines medicine Animals Humans Benzothiazoles Receptor Cells Cultured Conserved Sequence Acrylamides Sulfonamides Voltage-dependent calcium channel Chemistry General Neuroscience musculoskeletal neural and ocular physiology Thiourea Articles Thermoregulation medicine.disease Bridged Bicyclo Compounds Heterocyclic Rats Macaca fascicularis nervous system Capsaicin Blood-Brain Barrier lipids (amino acids peptides and proteins) Female psychological phenomena and processes Body Temperature Regulation
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(13)
ISSN:	1529-2401
Popis:	The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel that serves as a polymodal detector of pain-producing stimuli such as capsaicin, protons (pH in vivoand that TRPV1 antagonism and hyperthermia are not separable. TRPV1 antagonists caused hyperthermia in multiple species (rats, dogs, and monkeys), demonstrating that TRPV1 function in thermoregulation is conserved from rodents to primates. Together, these results indicate that tonic TRPV1 activation regulates body temperature.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a34b666086d066f19cba30d8b09e89c https://pubmed.ncbi.nlm.nih.gov/17392452 Zobrazit plný text záznamu