Landscape of genomic imprinting and its functions in the mouse mammary gland
| Autor: | Jihong Sun, Wei Chen, Li Zou, Xu Feng, Lina Zhao, Hong Yu, Baowei Jiao, Qin Yang, Haibo Xu, Yujie Ma |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
mammary gland
Mammary gland Biology AcademicSubjects/SCI01180 Genomic Imprinting Mammary Glands Animal Lactation Gene expression Genetics medicine Animals Cell Lineage Gene Regulatory Networks Epigenetics Cell Self Renewal Molecular Biology Gene Alleles imprinted gene network Stem Cells Gene Expression Regulation Developmental Embryo Cell Differentiation Cell Biology General Medicine Articles differentiation Cell biology stem cell Mice Inbred C57BL medicine.anatomical_structure imprinted gene Female Stem cell Genomic imprinting metabolism |
| Zdroj: | Journal of Molecular Cell Biology |
| ISSN: | 1759-4685 1674-2788 |
| Popis: | Genomic imprinting is an epigenetic modification of DNA, whereby gene expression is restricted to either maternally or paternally inherited alleles. Imprinted genes (IGs) in the placenta and embryo are essential for growth regulation and nutrient supply. However, despite being an important nutrition delivery organ, studies on mammary gland genomic imprinting remain limited. In this study, we found that both the number of IGs and their expression levels decreased during development of the mouse mammary gland. IG expression was lineage-specific and related to mammary gland development and lactation. Meta-analysis of single-cell RNA sequencing data revealed that mammary gland IGs were co-expressed in a network that regulated cell stemness and differentiation, which was confirmed by our functional studies. Accordingly, our data indicated that IGs were essential for the self-renewal of mammary gland stem cells and IG decline was correlated with mammary gland maturity. Taken together, our findings revealed the importance of IGs in a poorly studied nutrition-related organ, i.e. the mammary gland, thus providing a reference for further studies on genomic imprinting. |
| Databáze: | OpenAIRE |
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