Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats
| Autor: | Seiko Nagata, Takahiro Moriya, Akira Kono, Kyoko Miyasaka, Shigenobu Shibata, Akihiro Funakoshi, Takao Shimazoe, Shiro Yamanouchi, Miyuki Maetani, Shigenori Watanabe |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Light Central nervous system Diabetes Mellitus Experimental Internal medicine Diabetes mellitus Gene expression medicine Animals Circadian rhythm Rats Wistar Suprachiasmatic nucleus business.industry General Neuroscience medicine.disease Streptozotocin Rats medicine.anatomical_structure Endocrinology Hypothalamus Light induced Suprachiasmatic Nucleus business Proto-Oncogene Proteins c-fos medicine.drug |
| Zdroj: | Neuroscience letters. 227(2) |
| ISSN: | 0304-3940 |
| Popis: | We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long–Evans Tokushima Fatty (OLETF) rats as compared with control Long–Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ-induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN). |
| Databáze: | OpenAIRE |
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