Trimethylamine-N-oxide postprandial response in plasma and urine is lower after fermented compared to non-fermented dairy consumption in healthy adults

Autor: Nathalie Vionnet, Valentin Scherz, Linda H. Münger, Guy Vergères, Kathryn J Burton, Francesco Capozzi, Ralf Krüger, Gianfranco Picone, Claire Bertelli, Gilbert Greub
Přispěvatelé: Burton K.J., Kruger R., Scherz V., Munger L.H., Picone G., Vionnet N., Bertelli C., Greub G., Capozzi F., Vergeres G.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
fermented milks
lcsh:TX341-641
Trimethylamine N-oxide
TMAO
Urine
030204 cardiovascular system & hematology
Gut flora
Adolescent
Adult
Bacteria/metabolism
Biomarkers/blood
Biomarkers/urine
Cross-Over Studies
Cultured Milk Products
Dairy Products
Double-Blind Method
Feces/microbiology
Female
Gastrointestinal Microbiome
Humans
Male
Methylamines/blood
Methylamines/urine
Postprandial Period
Switzerland
Young Adult
choline
dairy products
microbiota
milk
Choline
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Fermented milk products
Food science
2. Zero hunger
Nutrition and Dietetics
biology
Microbiota
food and beverages
Metabolism
Fermented milk
biology.organism_classification
3. Good health
Dairy product
030104 developmental biology
Postprandial
Milk
chemistry
Fermentation
lcsh:Nutrition. Foods and food supply
Food Science
Zdroj: Nutrients
Volume 12
Issue 1
Nutrients, Vol 12, Iss 1, p 234 (2020)
Nutrients, vol. 12, no. 1, pp. 234
Popis: Trimethylamine-N-oxide (TMAO) can be produced by the gut microbiota from dietary substrates and is associated with cardiovascular disease. While dairy products contain TMAO precursors, the effect of fermented dairy on TMAO metabolism remains unclear. We used plasma and urine samples collected for two randomised cross-over studies to evaluate the effects of fermented dairy consumption on TMAO metabolism. In Study 1, thirteen healthy young men tested a yogurt and an acidified milk during postprandial tests and a two-week daily intervention. In Study 2, ten healthy adults tested milk and cheese during postprandial tests. TMAO and five related metabolites were measured in plasma and urine by LC-MS/MS and NMR. Faecal microbiota composition was assessed in Study 1 (16S rRNA metagenomics sequencing). Fermented milk products were associated with lower postprandial TMAO responses than non-fermented milks in urine (Study 1, p = 0.01
Study 2, p = 0.02) and in plasma, comparing yogurt and acidified milk (Study 1, p = 0.04). Daily consumption of dairy products did not differentially affect fasting TMAO metabolites. Significant correlations were observed between microbiota taxa and circulating or urinary TMAO concentrations. Fermentation of dairy products appear, at least transiently, to affect associations between dairy products and circulating TMAO levels.
Databáze: OpenAIRE
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