Potent Cyclic Tetrapeptide for Lead Detoxification
| Autor: | Tagwa A. Mohammed, Christoph M. Meier, Tadeáš Kalvoda, Martina Kalt, Lubomír Rulíšek, Michal S. Shoshan |
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| Přispěvatelé: | University of Zurich, Shoshan, Michal S |
| Rok vydání: | 2021 |
| Předmět: |
10120 Department of Chemistry
1503 Catalysis Cell Survival 1600 General Chemistry Peptide Pharmacology Cellular level 010402 general chemistry 01 natural sciences Peptides Cyclic Catalysis Lead poisoning Detoxification 540 Chemistry medicine Humans Chelation therapy chemistry.chemical_classification Tetrapeptide 010405 organic chemistry General Medicine General Chemistry medicine.disease 3. Good health 0104 chemical sciences chemistry Lead Toxicity HT29 Cells Oligopeptides Protein Binding |
| Zdroj: | Angewandte Chemie (International ed. in English). 60(22) |
| ISSN: | 1521-3773 |
| Popis: | Lead (Pb) is a ubiquitous poisonous metal, affecting the health of vast populations worldwide. Medications to treat Pb poisoning suffer from various limitations and are often toxic owing to insufficient metal selectivity. Here, we report a cyclic tetrapeptide that selectively binds Pb and eradicates its toxic effect on the cellular level, with superior potency than state-of-the-art drugs. The Pb-peptide complex is remarkably strong and was characterized experimentally and computationally. Accompanied by the lack of toxicity and enhanced stability of this peptide, these qualities indicate its merit as a potential remedy for Pb poisoning. |
| Databáze: | OpenAIRE |
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