Rare, yet emerging cause of graft dysfunction—ALECT 2 amyloidosis
| Autor: | Jasmine Sethi, Kulwant Singh, Rajan Duggal, Kusum Joshi, Arjinder S Bains |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Graft dysfunction Amyloid Transplant recipient 030232 urology & nephrology 030230 surgery lcsh:RC870-923 Graft function 03 medical and health sciences 0302 clinical medicine renal transplant alect2 amyloid medicine graft dysfunction Pathological Kidney Proteinuria business.industry Amyloidosis lcsh:Diseases of the genitourinary system. Urology medicine.disease medicine.anatomical_structure Nephrology medicine.symptom business |
| Zdroj: | Indian Journal of Nephrology, Vol 30, Iss 3, Pp 204-206 (2020) |
| ISSN: | 0971-4065 |
| DOI: | 10.4103/ijn.ijn_258_19 |
| Popis: | Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. Amyloidosis derived from leukocyte cell-derived chemotaxin 2 (LECT2) is a recently recognized form of amyloidosis in the United States with predominant involvement of kidney and liver. We present a case of ALECT2 renal amyloid in a transplant recipient who presented with gradual worsening of graft function and subnephrotic proteinuria. To our knowledge, this is first case of LECT2 amyloidosis from Northern India in a transplant recipient. There is no effective therapy for amyloidosis derived from leukocyte cell-derived chemotaxin 2. |
| Databáze: | OpenAIRE |
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