Does prenatal restraint stress change the craniofacial growth pattern of rat offspring?
| Autor: | Naser Asl Aminabadi, Saeed Sadigh-Eteghad, Ahmad Behroozian, Sajjad Shirazi, Mohammad Samiei, Elham Talatahari |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Litter (animal) Male Offspring Craniofacial abnormality Physiology Craniofacial Abnormalities 03 medical and health sciences 0302 clinical medicine Pregnancy Cranial vault Nasal septum Medicine Animals Chronic stress Rats Wistar General Dentistry business.industry 030206 dentistry Anatomy medicine.disease Rats 030104 developmental biology medicine.anatomical_structure Prenatal Exposure Delayed Effects Gestation Female business Stress Psychological |
| Zdroj: | European journal of oral sciences. 124(1) |
| ISSN: | 1600-0722 |
| Popis: | A major and frequently encountered condition underlying the long-term programming effects of the intrauterine environment is exposure to stress. Gestational stress is an environmental factor that induces physical and behavioral alterations in offspring. Seventy female virgin Wistar rats were mated with one male rat for a maximum of four times, after which 52 pregnant rats were divided into two groups. In the experimental group the rats were exposed to restraint stress during pregnancy, whereas the control group did not receive the stress protocol. One male litter was randomly chosen from the offspring of each rat with 8-13 pups. A total of 40 male rat offspring were available for analysis. Thirty-one linear and angular measurements were analyzed in both study groups to investigate whether prenatal restraint stress changes the craniofacial growth pattern of rat offspring. In the prenatally stressed group, anterior cranial base length and viscerocranium measures were significantly increased compared with the control group, whereas cranial width, mandibular dimensions, and posterior cranial height and length remained unchanged. Furthermore, the prenatally stressed group showed backward rotation of the midface and decreased flattening of the cranial vault. It was concluded that prenatal chronic stress can induce alterations in the craniofacial growth pattern by promoting endochondral growth in the cranial base and nasal septum. |
| Databáze: | OpenAIRE |
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