Comparative efficacy of three regimens (cyclosporine, tacrolimus, and cyclophosphamide) combined with steroids for the treatment of idiopathic membranous nephropathy
| Autor: | Lin Wei-yuan, Xing Fang, Du Zhen-shuang, Chen Ruo-ji, Zheng Zi-li, Zhang Yu-lin |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Creatinine
medicine.medical_specialty biology Cyclophosphamide business.industry Serum albumin medicine.disease Gastroenterology Idiopathic Membranous Nephropathy Tacrolimus Regimen chemistry.chemical_compound chemistry Nephrology Lower respiratory tract infection Internal medicine biology.protein Medicine business Adverse effect medicine.drug |
| Zdroj: | Nefrología. 42:671-679 |
| ISSN: | 0211-6995 |
| DOI: | 10.1016/j.nefro.2021.08.006 |
| Popis: | To investigate the efficacy of combined immunosuppressive regimens of cyclosporine (CsA), tacrolimus (TAC), or cyclophosphamide (CTX) combined with steroids in the treatment of idiopathic membranous nephropathy (IMN).A total of 150 biopsy-proven IMN patients were divided into three groups: CTX, TAC, and CsA groups (50 cases each). Patients received a selected regimen for 48 weeks. The efficacy (remission rate, 24h urinary protein, and serum albumin and creatinine) and safety (adverse events) profiles of administered regimens were evaluated at 12, 24 and 48 weeks.At 12 weeks, the response rates for CsA, TAC, and CTX groups were 14%, 50%, and 22%, respectively. This increased to 74%, 84%, and 82%, respectively at 48 weeks. During follow-up, 24h urinary protein significantly reduced from baseline in all regimens (P0.05), while serum albumin increased in TAC and CTX groups after 12 weeks (P0.05), and CsA group at 48 weeks (P0.05). No significant changes in serum creatinine levels were noted in all three regimens (P0.05). Safety was comparable in all groups, with lower respiratory tract infection being the most frequent adverse event.The combined regimens (i.e., TAC, CsA, and CTX) are effective in the treatment of patients with IMN at 48 weeks, while TAC and CTX might be more beneficial in terms of shortened time to remission and increased complete response rate. |
| Databáze: | OpenAIRE |
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