RCAN1 Regulates Bidirectional Synaptic Plasticity
| Autor: | Emilie Trillaud-Doppia, Anthony Dudilot, Jannic Boehm |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Long-Term Potentiation Neurotransmission Biology General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine LTP induction Animals Phosphorylation Long-term depression Neurons Glycogen Synthase Kinase 3 beta Mechanism (biology) Calcineurin Long-Term Synaptic Depression Intracellular Signaling Peptides and Proteins Long-term potentiation Rats 030104 developmental biology Synaptic plasticity General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current biology : CB. 30(7) |
| ISSN: | 1879-0445 |
| Popis: | Synaptic plasticity, with its two most studied forms, long-term potentiation (LTP) and long-term depression (LTD), is the cellular mechanism underlying learning and memory. Although it has been known for two decades that bidirectional synaptic plasticity necessitates a corresponding bidirectional regulation of calcineurin activity, the underlying molecular mechanism remains elusive. Using organotypic hippocampal slice cultures, we show here that phosphorylation of the endogenous regulator-of-calcineurin (RCAN1) by GSK3β underlies calcineurin activation and is a necessary event for LTD induction, while phosphorylation of RCAN1 at a PKA site blocks calcineurin activity, thereby allowing LTP induction. Our results provide a new mechanism for the regulation of calcineurin in bidirectional synaptic plasticity and establish RCAN1 as a "switch" for bidirectional synaptic plasticity. |
| Databáze: | OpenAIRE |
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