Reduced bacterial adhesion to heparin-surface-modified intraocular lenses
| Autor: | Marta Portolés, Fee-Lai Leong, Miguel F. Refojo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Staphylococcus aureus
medicine.medical_specialty genetic structures medicine.medical_treatment Colony Count Microbial Intraocular lens Methylmethacrylate medicine.disease_cause Bacterial Adhesion Microbiology Endophthalmitis Staphylococcus epidermidis Ophthalmology medicine Methylmethacrylates Lenses Intraocular biology Heparin Chemistry technology industry and agriculture Adhesion Cataract surgery equipment and supplies medicine.disease biology.organism_classification eye diseases Sensory Systems Intraocular lenses Pseudomonas aeruginosa Microscopy Electron Scanning Surgery sense organs medicine.drug |
| Zdroj: | Journal of Cataract and Refractive Surgery. 19:755-759 |
| ISSN: | 0886-3350 |
| DOI: | 10.1016/s0886-3350(13)80345-8 |
| Popis: | Bacterial adherence to intraocular lenses (IOLs) could be the cause of endophthalmitis following cataract surgery and lens implantation. There are previous reports that heparin bound to the surface of poly(methyl methacrylate) (PMMA) IOLs reduces cell adhesion. In this study, the in vitro adherence of Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa to regular PMMA IOLs and to heparin-surface-modified (HSM) PMMA IOLs was investigated. The three bacterial strains attached in significantly lower numbers to HSM-PMMA IOLs than to PMMA IOLs (P < .01). Heparin in solution also inhibited attachment of Staphylococcus epidermidis to regular PMMA IOLs. Heparin may reduce adherence by placing a highly hydrated layer between the bacteria and the IOL surface. Therefore, the use of HSM-PMMA IOLs could diminish the incidence of endophthalmitis. |
| Databáze: | OpenAIRE |
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