Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population
| Autor: | R.-F. Guo, She-Gan Gao, Keitaro Matsuo, J.-L. Li, Hua-Qin Guo, Xin He, Fan Zongmin, Lei Wang, L.-M. Yin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
China Esophageal Neoplasms Population Adenocarcinoma Thymidylate synthase Stomach Neoplasms Polymorphism (computer science) Genotype Humans Genetic Predisposition to Disease Promoter Regions Genetic education Methylenetetrahydrofolate Reductase (NADPH2) Aged Aged 80 and over education.field_of_study Polymorphism Genetic biology Gastroenterology Case-control study Cardia Thymidylate Synthase General Medicine Middle Aged Gastric Cardia Adenocarcinoma digestive system diseases Case-Control Studies Methylenetetrahydrofolate reductase DNA methylation Carcinoma Squamous Cell biology.protein Cancer research Female Signal Transduction |
| Zdroj: | Diseases of the Esophagus. 18:177-184 |
| ISSN: | 1442-2050 1120-8694 |
| DOI: | 10.1111/j.1442-2050.2005.00492.x |
| Popis: | SUMMARY. Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are key enzymes in folate metabolism, which is essential for normal DNA methylation and synthesis. Common polymorphisms at the MTHFR nucleotides position 677 (C-T) and a 28-bp tandem repeat polymorphism (2R or 3R) in the TS promoter enhancer region (TSER) have been reported to be functional and are supposed to disturb the normal DNA methylation and synthesis leading to carcinogenesis. To investigate the association between these polymorphisms and the risk of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA), we conducted a case-control study in the Anyang area where the incidence of ESCC is highest in northern China. Subjects consisted of 275 cases with ESCC, 129 cases with GCA and 310 sex- and age-matched cancer-free controls. The risk was evaluated in terms of age–sex adjusted odds ratios (ORs) and 95% confidence intervals (CIs) by unconditional logistic regression model. The ORs for the MTHFR677TT genotype compared with the MTHFR677CC/CT genotype were 1.62 (95% CI = 1.15–2.30) and 1.81 (1.17–2.81) for ESCC and GCA, respectively. The ORs for the TSER 2R/2R genotype relative to the other genotypes were 2.44 (0.89–6.73) and 3.94 (1.29–12.0) for SCC and GCA, respectively. These findings indicated that the folate metabolism plays an important role in carcinogenesis of ESCC and GCA and the common functionally polymorphisms MTHFRC677T and TSER have substantial influence in this metabolic pathway. |
| Databáze: | OpenAIRE |
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