Added value of anti-Müllerian hormone serum concentration in assisted reproduction clinical practice using highly purified human menopausal gonadotropin (HP-hMG)

Autor: Barrière, Paul, Porcu-Buisson, Géraldine, Avril, Catherine, Hamamah, Samir
Přispěvatelé: Le Bihan, Sylvie, Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre hospitalier universitaire de Nantes (CHU Nantes), Institut de Médecine de la Reproduction, Clinique Mathilde [Rouen], CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Développement Embryonnaire, Fertilité et Environnement (DEFE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Rok vydání: 2021
Předmět:
Adult
Anti-Mullerian Hormone
endocrine system
MESH: Biomarkers / blood
[SDV]Life Sciences [q-bio]
MESH: Anti-Mullerian Hormone / blood
MESH: Sperm Injections
Intracytoplasmic / methods
Fertilization in Vitro
Cohort Studies
Young Adult
In vitro fertilization
MESH: Infertility
Female / drug therapy
AMH
Humans
COS
Longitudinal Studies
Prospective Studies
Sperm Injections
Intracytoplasmic
MESH: Gonadotropins / administration & dosage
MESH: Longitudinal Studies
Ovarian Reserve
MESH: Cohort Studies
MESH: Humans
urogenital system
Obstetrics and Gynecology
MESH: Adult
MESH: Prospective Studies
MESH: Fertilization in Vitro / methods
[SDV] Life Sciences [q-bio]
Reproductive Medicine
MESH: Young Adult
HP-hMG
Female
MESH: Ovarian Reserve / drug effects
MESH: Female
Infertility
Female
hormones
hormone substitutes
and hormone antagonists
Biomarkers
Gonadotropins
Zdroj: Journal of Gynecology Obstetrics and Human Reproduction
Journal of Gynecology Obstetrics and Human Reproduction, 2021, 51 (2), pp.102289. ⟨10.1016/j.jogoh.2021.102289⟩
ISSN: 2468-7847
DOI: 10.1016/j.jogoh.2021.102289⟩
Popis: International audience; Introduction: The individual response to controlled ovarian stimulation (COS) depends on several factors, including the initial dose of gonadotropin. In repeated in vitro fertilization (IVF) cycles, the initial dose of gonadotropin is mainly established on the basis of the previous attempts' outcomes. Conversely, in naive patients, the ovarian response should be estimated using other criteria, such as the serum concentration of anti-M€ ullerian hormone (AMH). However, in clinical practice, the initial gonadotropin dose is not systematically adapted to the AMH level, despite the known relationship between AMH and ovarian reserve. Material and Methods: French non-interventional, longitudinal, prospective, multicentre, cohort study that included infertile women who underwent COS with highly purified human menopausal gonadotropin (HP-hMG 600 IU/mL) during their first IVF/intracytoplasmic sperm injection (ICSI) cycle. Data were collected prospectively during routine follow-up visits from COS initiation to 10−11 weeks after embryo transfer. Results: Data from 235 of the 297 enrolled women were used for the study. Serum AMH level was negatively correlated with the initial and total HP-hMG doses (p
Databáze: OpenAIRE
Externí odkaz: