Serum phospholipids fatty acids and breast cancer risk by pathological subtype
| Autor: | Antonio Antón, Beatriz Pérez-Gómez, Manuel Ramos-Vázquez, Inmaculada Criado-Navarro, Blanca Hernando, Angel Guerrero-Zotano, Raquel Andrés, Rosalia Caballero, Antonio Llombart-Cussac, Ana M. Casas, Miguel Martín, José Manuel Baena-Cañada, Begoña Bermejo, Virginia Lope, Montserrat Muñoz, Feliciano Priego-Capote, Ana de Juan, Adela Castelló, José A. García-Sáenz, Marina Pollán, Rosa María Franquesa, Pedro Sánchez-Rovira, Silvia Antolín |
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| Přispěvatelé: | Asociación Española Contra el Cáncer, Sociedad Española de Oncología Médica, Ministerio de Economía y Competitividad (España), Federación Española de Cáncer de Mama, Medicina, Fundación Científica AECC, [Lope,V, Pérez-Gómez,B, Castelló,A, Pollán,M] Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. [Lope,V, Pollán,M] Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain. [Lope,V, Guerrero-Zotano,Á, Casas,A, Baena-Cañada,JM, Bermejo,B, Antolí,S, Sánchez-Rovira,P, Ramos-Vázquez,M, Antón,A, García-Saénz,JÁ, Muñoz,M, de Juan,A, Andrés,R, Llombart-Cussac,A, Hernando,B, Franquesa,RM, Caballero,R, Martín,M, Pollán,M] GEICAM Spanish Breast Cancer Group, Madrid, Spain. [Guerrero-Zotano,Á] Instituto Valenciano de Oncología, Valencia, Spain. [Casas,A] Hospital Universitario Virgen Del Rocio, Sevilla, Spain. [Baena-Cañada,JM] Hospital Universitario Puerta del Mar, Cádiz, Spain. [Baena-Cañada,JM] Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain. [Bermejo,B] Hospital Clínico Universitario de Valencia, Valencia, Spain. [Bermejo,B] Biomedical Research Institute INCLIVA, Valencia, Spain. [Bermejo,B, Martín,M] CIBERONC, ISCIII, Madrid, Spain. [Criado-Navarro,I, Priego-Capote,F] Analytical Chemistry Department, Universidad de Córdoba, Córdoba, Spain. [Criado-Navarro,I, Priego-Capote,F] Maimónides Institute of Biomedical Research (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain. [Criado-Navarro,I, Priego-Capote,F] CIBERFES, ISCIII, Madrid, Spain. [Antolín,S] Medical Oncology Unit, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain. [Sánchez-Rovira,P] Complejo Hospitalario de Jaén, Jaén, Spain. [Ramos-Vázquez,M] Centro Oncológico de Galicia, A Coruña, Spain. [Antón,A] Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain. [Castell,A] Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain. [García-Saénz,JÁ] Hospital Clínico San Carlos, Madrid, Spain. [Muñoz,M] Medical Oncology, Hospital Clínic Barcelona, Barcelona, Spain. [Muñoz,M] Translational Genomics and Targeted Therapeutics, Institut d’Investigacions Biomèdiques Pi i Sunyer-IDIBAPS, Barcelona, Spain. [de Juan,A] Hospital Marqués de Valdecilla, Santander, Spain. [Andrés,R] Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain. [Llombart-Cussac,A] Hospital Arnau de Vilanova, Valencia, Spain. [Hernando,B] Hospital General Yagüe, Burgos, Spain. [Franquesa,RM] Hospital General de Vic, Barcelona, Spain. [Martín,M] Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Martín,M] Instituto Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Madrid, Spain., This study was funded by the Fundación Científica Asociación Española Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association against Cancer 2006 & 2016), Sociedad Española de Oncología Médica (SEOM) (Spanish Society of Medical Oncology), Ministerio de Economía y Competitividad (Spanish Ministry of Economy and Coiveness. IJCI-2014-20900), Fundación Cerveza y Salud 2005 (Beer and Health Foundation 2005) and Federación de Asociaciones de Mujeres con Cáncer de Mama (FECMA) (Spanish Federation of Associations of Women with Breast Cancer). This article presents independent research. The views expressed are those of the authors and not necessarily those of the Carlos III Institute of Health. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Àcids grassos Grasas Gastroenterology Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Fats chemistry.chemical_compound 0302 clinical medicine Breast cancer EpiGEICAM Surveys and Questionnaires Fosfolípidos Palmitoleic acid Ácidos grasos Phospholipids desaturation indices Nutrition and Dietetics Estudios de casos y controles Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings] Breast neoplasm Fatty Acids Chemicals and Drugs::Lipids::Fatty Acids [Medical Subject Headings] Middle Aged Elaidic acid 030220 oncology & carcinogenesis Neoplasias de la mama Female Stearic acid Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers Pharmacological [Medical Subject Headings] lcsh:Nutrition. Foods and food supply Adult Risk medicine.medical_specialty fats Phenomena and Processes::Mathematical Concepts::Probability::Risk [Medical Subject Headings] Linoleic acid Breast cancer subtypes Breast Neoplasms lcsh:TX341-641 Desaturation indices Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior [Medical Subject Headings] Article Information Science::Information Science::Data Collection::Questionnaires [Medical Subject Headings] Càncer de mama 03 medical and health sciences breast neoplasm Internal medicine Biomarkers Tumor medicine Humans Fatty acids Persons::Persons::Age Groups::Adult [Medical Subject Headings] Chemicals and Drugs::Lipids::Phospholipids [Medical Subject Headings] Life Style Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings] Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings] business.industry Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] Feeding Behavior Odds ratio medicine.disease Confidence interval breast cancer subtypes 030104 developmental biology Check Tags::Female [Medical Subject Headings] chemistry Spain Case-Control Studies business Body mass index Food Science |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Nutrients r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname Volume 12 Issue 10 Nutrients, Vol 12, Iss 3132, p 3132 (2020) Zaguán. Repositorio Digital de la Universidad de Zaragoza Zaguán: Repositorio Digital de la Universidad de Zaragoza Universidad de Zaragoza Nutrients 2020, 12(10), 3132 Repisalud Instituto de Salud Carlos III (ISCIII) RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz Universidad de Cádiz r-FISABIO. Repositorio Institucional de Producción Científica RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz |
| ISSN: | 2072-6643 |
| Popis: | This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44 95% confidence interval (CI) = 0.30&ndash 0.66), linoleic acid (ORT3vsT1 = 0.66 95% CI = 0.49&ndash 0.90) and arachidonic to dihomo-&gamma linolenic acid ratio (OR T3vsT1 = 0.64 95% CI = 0.48&ndash 0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65 95% CI = 1.20&ndash 2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51 95% CI = 1.12&ndash 2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52 95% CI = 1.14&ndash 2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04 95% CI = 1.45&ndash 2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices. |
| Databáze: | OpenAIRE |
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