| Autor: |
Marlin Yohn, Matthew Sim, Andrew Wright, Amanda R. Schabdach, Preston S. Donover, Melvin Reichman, Chip Allee, Sandesh Gowda |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Combinatorial Chemistry & High Throughput Screening. 16:180-188 |
| ISSN: |
1386-2073 |
| Popis: |
The Lankenau Institute for Medical Research Chemical Genomics Center, Inc. has developed a new (patents issued and pending) Nanotube Automated Repository System (NARS) for dynamic storage of millions of 'single-shot' samples stored in a new monolithic microtiter-storage tube plate of our own design we call 'nanotubes.' We have integrated the NARS with customized software to efficiently access up to 10,000,000 samples stored continuously frozen (-20°C) in a dehumidified enclosure and sealed in a new microtiter NARS plate that is SBS compliant. Additional software was developed to analyze HTS data from orthogonally pooled compound libraries. Following 'de-convolution' of pooled HTS data, the software designates confirmatory retest samples to be 'cherry-picked' using the NARS. The application of a new, fully-integrated infrastructure for new leads discovery is described in detail. Other applications for our technologies and new infrastructure are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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