CD11b/CD18 expression, adherence, and chemotaxis of granulocyte in adult respiratory distress syndrome
| Autor: | V Von Fliedner, Marie-Denise Schaller, Michele Markert, T Laurent, M C Tagan, René Chioléro, Claude Perret, François Feihl |
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| Rok vydání: | 1994 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult ARDS Pulmonary Circulation Time Factors Gene Expression CD18 Granulocyte Critical Care and Intensive Care Medicine Antigens CD medicine Cell Adhesion Humans Granulocyte chemotaxis Aged Respiratory Distress Syndrome Respiratory distress biology Receptors Leukocyte-Adhesion business.industry CD11 Antigens Respiratory disease Chemotaxis Middle Aged medicine.disease N-Formylmethionine Leucyl-Phenylalanine Chemotaxis Leukocyte medicine.anatomical_structure Integrin alpha M CD18 Antigens Case-Control Studies Immunology biology.protein business Granulocytes |
| Zdroj: | American journal of respiratory and critical care medicine. 149(6) |
| ISSN: | 1073-449X |
| Popis: | The accumulation of granulocytes in the pulmonary microvasculature is generally thought a cardinal event in the pathology of adult respiratory distress syndrome (ARDS). However, the mechanism by which granulocytes are sequestered in the pulmonary vascular bed remains largely unknown. Because the CD11b/CD18 membrane receptors mediate various adhesion-dependent functions, their expression was investigated in granulocytes from patients during the course of ARDS development in relation to adherence and chemotaxis. CD11b expression of ARDS resting granulocytes was increased within 24 h of ARDS onset by a factor of two in comparison with control patients (p < 0.05) and remained significantly increased 72 to 120 h later. In contrast, the stimulated expression was significantly decreased only within 24 h of ARDS onset. Adherence was not modified within 8 h of the onset of ARDS, but was increased at Days 1, 3, and 5. The time course of granulocyte chemotaxis shows a decreased chemotaxis capacity during the first 3 d of ARDS, followed by normalization at Day 5. The dynamic changes observed in the various functions studied indicate a possible relationship between the modulation of the CD11b expression and a hyperadhesive state of granulocytes in ARDS. These sticky granulocytes may potentially contribute to the microvascular injury. |
| Databáze: | OpenAIRE |
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