Type 2 Diabetes in Relation to the Risk of Renal Cell Carcinoma Among Men and Women in Two Large Prospective Cohort Studies
| Autor: | Kathryn M. Wilson, Yanping Li, Glen W. Barrisford, Qi Sun, Alejandro Sanchez, Deirdre K Tobias, Mark A. Preston, Dayron Rodriguez, Rebecca E. Graff, Eunyoung Cho, Michael L. Blute |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Research design medicine.medical_specialty Endocrinology Diabetes and Metabolism 030232 urology & nephrology Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Risk Factors Renal cell carcinoma Internal medicine Diabetes mellitus Internal Medicine medicine Humans Prospective Studies Epidemiology/Health Services Research Prospective cohort study Carcinoma Renal Cell Aged Advanced and Specialized Nursing business.industry Proportional hazards model Confounding Hazard ratio Middle Aged medicine.disease Kidney Neoplasms Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Female business Follow-Up Studies |
| Zdroj: | Diabetes Care. 41:1432-1437 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc17-2518 |
| Popis: | OBJECTIVE We assessed whether type 2 diabetes is associated with renal cell carcinoma (RCC), independent of key potential confounders, in two large prospective cohorts with biennially updated covariate data. RESEARCH DESIGN AND METHODS A total of 117,570 women from the Nurses’ Health Study (NHS) and 48,866 men from the Health Professionals Follow-Up Study (HPFS) were followed from 1976 and 1986, respectively, through 2014. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% CIs for associations between type 2 diabetes and pathology-confirmed RCC, overall and by stage, grade, and histologic subtype. RESULTS During 38 years of follow-up in the NHS, we confirmed 418 RCC case subjects, including 120 fatal cases. Over 28 years in the HPFS, we confirmed 302 RCC case subjects, including 87 fatal cases. Women with type 2 diabetes had a significantly increased risk of RCC compared with women without type 2 diabetes (multivariable HR 1.53; 95% CI 1.14–2.04), with some evidence that the association was stronger for ≤5 (HR 2.15; 95% CI 1.44–3.23) than >5 (HR 1.22; 95% CI 0.84–1.78) years’ duration of type 2 diabetes (Pdifference 0.03). Among men, type 2 diabetes was not associated with total RCC (HR 0.89; 95% CI 0.56–1.41) or with RCC defined by stage, grade, or subtype. Sample sizes for analyses by stage, grade, and subtype were limited. CONCLUSIONS We found that type 2 diabetes was independently associated with a greater risk of RCC in women but not in men. |
| Databáze: | OpenAIRE |
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